Intra-gastric pH following single oral administrations of rabeprazole and esomeprazole: double-blind cross-over comparison

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Author(s)

    • Furuta Kenji
    • Department of Gastroenterology and Hepatology, Shimane University School of Medicine
    • Nio Kenta
    • Department of Internal Medicine, Saga Medical School
    • Kusano Motoyasu
    • Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital
    • Kawami Noriyuki
    • Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine
    • Iwakiri Katsuhiko
    • Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine
    • Kohata Yukie
    • Department of Gastroenterology, Osaka City University Graduate School of Medicine
    • Aimi Masahito
    • Department of Gastroenterology and Hepatology, Shimane University School of Medicine
    • Naora Kohji
    • Department of Pharmacy, Shimane University Hospital, Shimane University School of Medicine
    • Arakawa Tetsuo
    • Department of Gastroenterology, Osaka City University Graduate School of Medicine
    • Kinoshita Yoshikazu
    • Department of Gastroenterology and Hepatology, Shimane University School of Medicine
    • Fujiwara Yasuhiro
    • Department of Gastroenterology, Osaka City University Graduate School of Medicine
    • Uotani Takahiro
    • First Department of Medicine, Hamamatsu University School of Medicine
    • Yamade Mihoko
    • First Department of Medicine, Hamamatsu University School of Medicine
    • Sahara Shu
    • First Department of Medicine, Hamamatsu University School of Medicine
    • Ichikawa Hitomi
    • First Department of Medicine, Hamamatsu University School of Medicine
    • Furuta Takahisa
    • Center for Clinical Research, Hamamatsu University School of Medicine

Abstract

Comparisons between the acid inhibitory effects of rabeprazole and esomeprazole after single oral administration with standard doses have not been previously presented. We examined intra-gastric pH after oral administrations of these two proton pump inhibitors using 24-h pH monitoring. Fifty-four normal volunteers not infected by <i>Helicobacter pylori</i> were investigated. Using a cross-over design, we administered 10 mg of rabeprazole or 20 mg of esomeprazole in 27 at 30 min after supper and in the remaining 27 subjects at 15 min before supper, and performed 24-h pH monitoring. Intra-gastric pH data were nearly identical when the proton pump inhibitors were taken after meals. Even if the data were compared in different CYP2C19 genotypes, rabeprazole and esomeprazole did not show the difference. In poor metabolizer, both of the drugs showed stronger acid inhibition. When taken before meals, intra-gastric pH after esomeprazole administration was slightly but not significantly higher than that observed after rabeprazole administration not only in daytime but also in nighttime period. In conclusion, rabeprazole and esomeprazole were similarly effective when administered after a meal.

Journal

  • Journal of Clinical Biochemistry and Nutrition

    Journal of Clinical Biochemistry and Nutrition 55(3), 178-183, 2014

    SOCIETY FOR FREE RADICAL RESEARCH JAPAN

Codes

  • NII Article ID (NAID)
    130004694546
  • Text Lang
    ENG
  • ISSN
    0912-0009
  • Data Source
    J-STAGE 
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