A proposal of a new intermittent androgen suppression therapy method for prostate cancer with saddle type instability

• Suzuki Yasuyuki

• Sakai Daichi

• Hirata Yoshito

• Aihara Kazuyuki

• Nomura Taishin

Bibliographic Information

Other Title

• サドル型不安定性を利用した新しい前立腺癌間欠的アンドロゲン抑制療法の提案

Abstract

The number of patients of prostate cancer is rapidly increasing. It is known that androgen enhances the growth of prostate cancer. Thus, continuous androgen suppression therapy, e.g. surgical castration and continuous medication, is used as the main form of therapy. However, many patients suffer from a relapse of the cancer. The relapse is rooted in changes of prostate cancer from androgen dependent to androgen independent. Intermittent androgen suppression (IAS) is a strategy to delay or possibly prevent the relapse. To prevent the prostate cancer from acquiring proliferating ability under the low androgen concentration condition, off-treatment periods in IAS therapy play an important role. Ideta et al. and Hirata et al. mathematically describe the dynamics of a tumor being treated by IAS. Analyses of these models show that the existing protocol of IAS therapy can be improved by our new protocol based on the region-dividing control.

Journal

• Transactions of Japanese Society for Medical and Biological Engineering

  Transactions of Japanese Society for Medical and Biological Engineering 52 (Supplement), O-424-O-425, 2014

  Japanese Society for Medical and Biological Engineering

Details

• CRID: 1390282680243904768
• NII Article ID: 130004695855
• DOI: 10.11239/jsmbe.52.o-424
• ISSN: 18814379
• ISSN: 1347443X
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed