Evaluation of Relationship between Inhalation of <sup>131</sup>I Thyroid Uptake and Administration Time of Stable Iodine Tablets～Calculation for Japanese by Using Biokinetic Models～

TANI Kotaro, KURIHARA Osamu, KOSAKO Toshiso

doi:10.3769/radioisotopes.63.461

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安定ヨウ素剤投与時期の<sup>131</sup>I甲状腺摂取率抑制効果の評価～体内動態モデルによる日本人を対象とした計算～
安定ヨウ素剤投与時期の¹³¹I甲状腺摂取率抑制効果の評価 : 体内動態モデルによる日本人を対象とした計算
アンテイヨウソザイトウヨジキノ ¹ ³ ¹ I コウジョウセンセッシュリツヨクセイコウカノヒョウカ : タイナイドウタイモデルニヨルニホンジンオタイショウトシタケイサン
Evaluation of Relationship between Inhalation of 131I Thyroid Uptake and Administration Time of Stable Iodine Tablets～Calculation for Japanese by Using Biokinetic Models～

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Abstract

Thyroid uptake of radioactive iodine incorporated into the body is inhibited by the administration of stable iodine tablets. In this paper, the thyroid retention functions in the case of the acute inhalation of ¹³¹I for Japanese were analyzed by using the biokinetic models of radioactive and stable iodine. The influence of the Wolff-Chaikoff effect that the composition of thyroid hormone is temporarily inhibited by the intake of superfluous stable iodine is newly taken into consideration in the analysis of stable iodine. By comparing the computed thyroid retention functions between with and without the administration of stable iodine tablets, the inhibitory effects of the ¹³¹I thyroid uptake are evaluated. As a result, the inhibitory effect reaches about 50% when administration was conducted 2days before ¹³¹I intake and it increases more than 80% in case of from 1day to just before the intake. On the other hand, the inhibitory effect falls rapidly when administration was conducted after the intake, resulting in 20% or less than 7% in case of 12hours or 1day after the intake.

Journal

RADIOISOTOPES

RADIOISOTOPES 63 (10), 461-469, 2014

Japan Radioisotope Association

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