Risk Stratification in Patients With Brugada Syndrome Without Previous Cardiac Arrest

• Okamura Hideo

  Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center Department of Advanced Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Kamakura Tsukasa

  Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center

• Morita Hiroshi

  Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University

• Tokioka Koji

  Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University

• Nakajima Ikutaro

  Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center

• Wada Mitsuru

  Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center

• Ishibashi Kohei

  Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center

• Miyamoto Koji

  Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center Department of Advanced Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Noda Takashi

  Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center

• Aiba Takeshi

  Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center

• Nishii Nobuhiro

  Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University

• Nagase Satoshi

  Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University

• Shimizu Wataru

  Department of Advanced Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University Department of Cardiovascular Medicine, Nippon Medical School

• Yasuda Satoshi

  Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center Department of Advanced Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Ogawa Hisao

  Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Kamakura Shiro

  Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center

• Ito Hiroshi

  Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University

• Ohe Tohru

  Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University

• Kusano Kengo F.

  Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center Department of Advanced Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University

Bibliographic Information

Other Title

• Risk Stratification in Patients With Brugada Syndrome Without Previous Cardiac Arrest : Prognostic Value of Combined Risk Factors
• – Prognostic Value of Combined Risk Factors –

Abstract

Background:Risk stratification in patients with Brugada syndrome for primary prevention of sudden cardiac death is still an unsettled issue. A recent consensus statement suggested the indication of implantable cardioverter defibrillator (ICD) depending on the clinical risk factors present (spontaneous type 1 Brugada electrocardiogram (ECG) [Sp1], history of syncope [syncope], and ventricular fibrillation during programmed electrical stimulation [PES+]). The indication of ICD for the majority of patients, however, remains unclear.Methods and Results:A total of 218 consecutive patients (211 male; aged 46±13 years) with a type 1 Brugada ECG without a history of cardiac arrest who underwent evaluation for ICD including electrophysiological testing were examined retrospectively. During a mean follow-up period of 78 months, 26 patients (12%) developed arrhythmic events. On Kaplan-Meier analysis patients with each of Sp1, syncope, or PES+ suffered arrhythmic events more frequently (P=0.018, P<0.001, and P=0.003, respectively). On multivariate analysis Sp1 and syncope were independent predictors of arrhythmic events. When dividing patients according to the number of these 3 risk factors present, patients with 2 or 3 risk factors experienced arrhythmic events more frequently than those with 0 or 1 risk factor (23/93 vs. 3/125; P<0.001).Conclusions:Syncope, Sp1, and PES+ are important risk factors and the combination of these risks well stratify the risk of later arrhythmic events. (Circ J 2015; 79: 310–317)

Journal

• Circulation Journal

  Circulation Journal 79 (2), 310-317, 2015

  The Japanese Circulation Society

Keywords

• Brugada syndrome
• Electrophysiological study
• Primary prevention
• Risk stratification
• Syncope

Details

• CRID: 1390001205108554112
• NII Article ID: 130004704033
• NII Article ID: 40020333910
• NII Book ID: AA11591968
• DOI: 10.1253/circj.cj-14-1059
• ISSN: 13474820
• ISSN: 13469843
• NDL BIB ID: 026048893
• PubMed: 25428522
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026048893
• Web Site: https://www.jstage.jst.go.jp/article/circj/79/2/79_CJ-14-1059/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015295081
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed