Increase of Type 2 Ryanodine Receptors in Mouse Nucleus Accumbens in the Development and Expression of Morphine-Induced Place Preference

• Kurokawa Kazuhiro

  Department of Pharmacology, Kawasaki Medical School, Japan

• Mizuno Koji

  Department of Pharmacology, Kawasaki Medical School, Japan

• Ohkuma Seitaro

  Department of Pharmacology, Kawasaki Medical School, Japan

抄録

The present study investigated the effect of ryanodine receptors (RyRs) in the development and expression of morphine-induced conditioned place preference (CPP). Type 2 RyRs (RyRs-2) in the nucleus accumbens (NAcc) significantly increased in morphine-conditioned mice, whereas type 1, 2, and 3 RyRs in the frontal cortex and ventral tegmental area showed no changes. Intracerebroventricular pretreatment with dantrolene, a RyRs antagonist, during the conditioning phase of CPP, dose-dependently inhibited morphine-induced CPP. The expression of morphine-induced CPP was abolished by dantrolene administration before the post-conditioning test. These findings suggest that RyRs-2 in the NAcc participate in the development and expression of morphine-induced CPP.

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 126 (3), 285-290, 2014

  公益社団法人 日本薬理学会

キーワード

• Type 2 ryanodine receptor
• morphine
• conditioned place preference

詳細情報

• CRID: 1390001205180783360
• NII論文ID: 130004704281
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.14147sc
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 025925125
• PubMed: 25367193
• Web Site: http://id.ndl.go.jp/bib/025925125
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025925125
• Web Site: https://www.jstage.jst.go.jp/article/jphs/126/3/126_14147SC/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015248653
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可