Effects of Propofol on Electrocardiogram Measures in Mice

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  • Shintaku Tomohiro
    Department of Pharmacology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Japan
  • Ohba Takayoshi
    Department of Cell Physiology, Akita University, Graduate School of Medicine, Japan
  • Niwa Hidetoshi
    Department of Anesthesiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Japan
  • Kushikata Tetsuya
    Department of Anesthesiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Japan
  • Hirota Kazuyoshi
    Department of Anesthesiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Japan
  • Ono Kyoichi
    Department of Cell Physiology, Akita University, Graduate School of Medicine, Japan
  • Matsuzaki Yasushi
    Department of Dermatology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Japan
  • Imaizumi Tadaatsu
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Japan
  • Kuwasako Kenji
    Division for Identification and Analysis of Bioactive Peptides, University of Miyazaki, Japan
  • Sawamura Daisuke
    Department of Dermatology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Japan
  • Murakami Manabu
    Department of Pharmacology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Japan

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Abstract

We investigated the anesthetic effects of propofol on the electrocardiogram (ECG) in mice. We also compared the effects of isoflurane (2%) inhalation anesthesia, intraperitoneal propofol (50 or 100 mg/kg), and pentobarbital (50 mg/kg) on ECG in mice. Isoflurane inhalation and pentobarbital anesthesia were both associated with an acceptable heart rate (HR) range (ca. 450 – 500 bpm). In contrast, high-dose propofol anesthesia significantly decreased the HR. Importantly, propofol anesthesia led to significantly reduced responses to propranolol, a β-blocker, suggesting that it affects sympathetic tonus and is not suitable for the evaluation of cardiovascular or sympathetic function. Propofol also reduced the response to atropine, indicative of suppression of mouse parasympathetic nerve activity. Our data suggest that propofol anesthesia should not be the first choice for cardiovascular analysis in mice.

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