Molecular Epidemiology of Dengue Viruses Co-circulating in Upper Myanmar in 2006

DOI 機関リポジトリ HANDLE 参考文献11件 オープンアクセス
  • Thant Kyaw Zin
    Department of Molecular Epidemiology, Institute of Tropical Medicine, Nagasaki University Virology Research Division, Department of Medical Research (Upper Myanmar)
  • Tun Mya Myat Ngwe
    Department of Virology, Institute of Tropical Medicine, Nagasaki University Global COE Program, 21<sup>st</sup> Century COE Program, MEXT
  • Parquet Maria del Carmen
    Department of Virology, Institute of Tropical Medicine, Nagasaki University Global COE Program, 21<sup>st</sup> Century COE Program, MEXT
  • Inoue Shingo
    Department of Virology, Institute of Tropical Medicine, Nagasaki University Global COE Program, 21<sup>st</sup> Century COE Program, MEXT
  • Lwin Yee Yee
    Virology Research Division, Department of Medical Research (Upper Myanmar)
  • Lin Sanda
    Virology Research Division, Department of Medical Research (Upper Myanmar)
  • Aye Kay Thi
    Virology Research Division, Department of Medical Research (Lower Myanmar)
  • Khin Pe Thet
    Department of Child Health, University of Medicine
  • Myint Tin
    University of Medicine (II)
  • Htwe Khin
    Department of Child Health, University of Medicine (I)
  • Nabeshima Takeshi
    Department of Virology, Institute of Tropical Medicine, Nagasaki University Global COE Program, 21<sup>st</sup> Century COE Program, MEXT
  • Morita Kouichi
    Department of Virology, Institute of Tropical Medicine, Nagasaki University Global COE Program, 21<sup>st</sup> Century COE Program, MEXT

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抄録

To understand the molecular epidemiology of circulating dengue viruses (DENV) in Upper Myanmar, DENV isolation was attempted by inoculating the sera of a panel of 110 serum samples onto a C6/36 mosquito cell line. The samples were collected from dengue (DEN) patients admitted at Mandalay Children’s Hospital in 2006. Infected culture fluids were subjected to a RT-PCR to detect the DENV genome. Three DENV strains were isolated. This was the first DENV isolation performed either in Mandalay or in Upper Myanmar. One strain belonged to DENV serotype-3 (DENV-3), and two other strains belonged to DENV serotype-4 (DEN-4). The sequence data for the envelope gene of these strains were used in a phylogenetic comparison of DENV-3 and DENV-4 from various countries. Phylogenetic analyses revealed that this DENV-3 strain was clustered within genotype II, and the two DENV-4 strains were clustered within genotype I in each serotype. The Myanmar strains were closely related to strains from the neighboring countries of Thailand and Bangladesh. These results are important for elucidating the trends of recent and future DEN outbreaks in Myanmar.

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