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- Yamanouchi Masashi
- Department of General Medicine, Juntendo University School of Medicine, Japan
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- Uehara Yuki
- Department of General Medicine, Juntendo University School of Medicine, Japan
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- Yokokawa Hirohide
- Department of General Medicine, Juntendo University School of Medicine, Japan
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- Hosoda Tomohiro
- Department of General Medicine, Juntendo University School of Medicine, Japan
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- Watanabe Yukiko
- Department of General Medicine, Juntendo University School of Medicine, Japan
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- Shiga Takayoshi
- Department of General Medicine, Juntendo University School of Medicine, Japan
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- Inui Akihiro
- Department of General Medicine, Juntendo University School of Medicine, Japan
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- Otsuki Yukiko
- Department of General Medicine, Juntendo University School of Medicine, Japan
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- Fujibayashi Kazutoshi
- Department of General Medicine, Juntendo University School of Medicine, Japan
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- Isonuma Hiroshi
- Department of General Medicine, Juntendo University School of Medicine, Japan
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- Naito Toshio
- Department of General Medicine, Juntendo University School of Medicine, Japan
この論文をさがす
抄録
Objective The causes of fever of unknown origin (FUO) vary depending on the region and time period. We herein present a study of patients with classic FUO where we investigated differences based on patient background factors, such as age and causative diseases, and changes that have occurred over time.<br> Methods We extracted and analyzed data from the medical records of 256 patients ≥18 years old who met the criteria for classic FUO and were hospitalized between August, 1994 and December, 2012.<br> Results The median age of the patients was 55 years (range: 18-94 years). The cause of FUO was infection in 27.7% of the patients (n=71), non-infectious inflammatory disease (NIID) in 18.4% (47), malignancy in 10.2% (26), other in 14.8% (38), and unknown in 28.9% (74). The most common single cause was human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (n=17). NIID and malignancy were more common in patients ≥65 years old than in patients <65 years old. During 2004-2012, compared to 1994-2003, infections and "other" causes were decreased, whereas NIID, malignancy, and unknown causes were increased.<br> Conclusion FUO associated with HIV/AIDS is increasing in Japan. In addition, as in previous studies in Japan and overseas, our study showed that the number of patients in whom the cause of FUO remains unknown is increasing and exceeds 20% of all cases. The present study identified diseases that should be considered in the differential diagnosis of FUO, providing useful information for the future diagnosis and treatment of FUO.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 53 (21), 2471-2475, 2014
一般社団法人 日本内科学会