Intestinal Peyer’s patches prevent tumorigenesis in <i>Apc</i>^Min/+ mice

• Fujimoto Kyoko

  Division of Molecular Biology, Nagasaki International University

• Fujii Gen

  Division of Cancer Prevention Research, National Cancer Center Research Institute

• Sakurai Hitomi

  Division of Molecular Biology, Nagasaki International University

• Yoshitome Hiroko

  Division of Molecular Biology, Nagasaki International University

• Mutoh Michihiro

  Division of Cancer Prevention Research, National Cancer Center Research Institute

• Wada Morimasa

  Division of Molecular Biology, Nagasaki International University

Bibliographic Information

Other Title

• Intestinal Peyer’s patches prevent tumorigenesis in ApcMin/+ mice

Abstract

Peyer’s patches are nodules that play a central role in intestinal immunity. Few studies demonstrate the relationship between the number of Peyer’s patches and intestinal polyps. Here we identify a statistically significant inverse correlation between the quantity of Peyer’s patches and of the development of intestinal polyps in Apc^Min/+ mice, which are a useful model to clarify the role of Peyer’s patches in intestinal tumorigenesis. Using this model, we increased the number of Peyer’s patches using 0.1% and 1% corn husk arabinoxylan through feed. Intestinal polyp formation significantly decreased, concomitant with an increase in Peyer’s patches development (n = 12/group). In Aly^−/−Apc^Min/+ mice (negative control; no Peyer’s patches) there was no change in the amount of intestinal polyps (n = 10/group). Immune reaction following corn husk arabinoxylan treatment was measured by cytokine array. Increasing the number of Peyer’s patches decreased interleukin-17 production, which showed a dose dependent correlation with transcription factor/lymphoid enhancer-binding factor. This study identified a relationship between levels of Peyer’s patches and intestinal polyp formation, partly explained by the involvement of interleukin-17 production and β-catenin signaling in Apc^Min/+ mice.

Journal

• Journal of Clinical Biochemistry and Nutrition

  Journal of Clinical Biochemistry and Nutrition 56 (1), 43-48, 2015

  SOCIETY FOR FREE RADICAL RESEARCH JAPAN

Keywords

• Peyer’s patch
• corn husk arabinoxylan
• intestinal polyp
• cancer prevention
• <i>Apc</i>^Min/+ mouse

Details

• CRID: 1390001204671980928
• NII Article ID: 130004704978
• DOI: 10.3164/jcbn.14-115
• ISSN: 18805086
• ISSN: 09120009
• Web Site: https://search.jamas.or.jp/link/ui/2016045653
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed