Fatal Visceral Varicella-Zoster Developing Early after Autologous Hematopoietic Stem Cell Transplantation for Refractory Diffuse Large B-Cell Lymphoma
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- Ichikawa Satoshi
- Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine Department of Hematology, Osaki Citizen Hospital
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- Kim Mihyun
- Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
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- Hasegawa Shin
- Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
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- Ohashi Keiichi
- Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
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- Kondo Aiko
- Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
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- Kato Hiroki
- Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
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- Kamata Mayumi
- Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
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- Okitsu Yoko
- Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
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- Fukuhara Noriko
- Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
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- Onishi Yasushi
- Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
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- Ishizawa Kenichi
- Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
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- Harigae Hideo
- Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
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Abstract
A middle-aged woman who had undergone autologous hematopoietic stem cell transplantation (HSCT) 1 month previously suffered severe epigastralgia and relapse of lymphoma. The epigastralgia was not relieved by chemotherapy. Thereafter, her pancreatic and hepatic enzyme levels were markedly elevated and disseminated varicella emerged. Despite acyclovir administration, her general condition deteriorated rapidly and she died. Serum varicella zoster virus (VZV) DNA level was shown to be elevated and a diagnosis of disseminated VZV infection was established postmortem. In patients with severe abdominal pain following HSCT, early suspicion and therapeutic intervention for VZV are important, even in the absence of skin lesions.
Journal
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- Journal of Clinical and Experimental Hematopathology
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Journal of Clinical and Experimental Hematopathology 54 (3), 237-241, 2014
The Japanese Society for Lymphoreticular Tissue Research
