A case of a HBV carrier with HDV superinfection treated by PEG-IFN

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  • Kusakabe Atsunori
    Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital
  • Tanaka Yasuhito
    Department of Virology ＆ Liver unit, Nagoya City University Graduate School of Medical Sciences
  • Iio Etsuko
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
  • Murakami Shuko
    Department of Virology ＆ Liver unit, Nagoya City University Graduate School of Medical Sciences
  • Matsuura Kentaro
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
  • Shinkai Noboru
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
  • Miyaki Tomokatsu
    Department of Gastroenterology, Toyokawa City Hospital
  • Fujiwara Kei
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
  • Nojiri Shunsuke
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
  • Orito Etsuro
    Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital
  • Joh Takashi
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences

Bibliographic Information

Other Title
  • B型・D型肝炎ウイルス重複感染による肝障害に対してペグインターフェロンが有効であった1例
  • 症例報告 B型・D型肝炎ウイルス重複感染による肝障害に対してペグインターフェロンが有効であった1例
  • ショウレイ ホウコク Bガタ ・ Dガタ カンエンウイルス チョウフク カンセン ニ ヨル カン ショウガイ ニ タイシテ ペグインターフェロン ガ ユウコウ デ アッタ 1レイ

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Abstract

A 26-year-old Mongolian woman was admitted to our hospital because of liver dysfunction. As she has been a HBV carrier, acute exacerbation of chronic hepatitis B seemed to be the cause of liver dysfunction at first. However, the loads of serum HBV-DNA on admission were low (2.8 log copy/ml). As she was pregnant, she was observed without treatment. Liver function once improved without treatment, but it became worse again after delivery. At this time, it was suspected HDV superinfection could affect the liver dysfunction. For HDV-RNA was positive in stored sera by RT-PCR, she was diagnosed as HBV and HDV superinfection and started treatment with Peg-IFN. Although HDV infection is rare in Japan, in case of acute exacerbation of a HBV carrier with low serum HBV-DNA level, HBV and HDV superinfection should be considered.

Journal

  • Kanzo

    Kanzo 55 (11), 653-660, 2014

    The Japan Society of Hepatology

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