生体内腐食環境と生体材料  [in Japanese] <i>In vivo</i> Corrosion Environment and Biomaterials  [in Japanese]

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Abstract

生体内は塩化物イオンを含み,急激な温度変化や細胞による活性酸素種の産生など,金属材料にとって過酷な腐食環境である.生体内で金属材料に生じる腐食反応について概観し,金属イオンが誘発する細胞応答について述べる.一方で生命活動に必須である金属イオンの細胞機能調節における役割について紹介する.最後に,骨の力学的機能を支配する異方性微細構造に着目し,細胞制御により骨配向性制御を可能とする生体材料開発について最近の研究動向を紹介する.

Physiological environments are severe corrosive conditions which allow the metallic biomaterials to be oxidized by the surroundings including the cell activities. Corrosion reactions in biological conditions and their effects on cellular responses including immunological responses are reviewed. On the other hand, metal ions play essential roles in cellular activities by regulating the gene expression, enzyme activities and also the intracellular signaling pathways. Cellular activities mediated by metal ions are briefly reviewed. Finally, the hierarchical anisotropic architecture of bone is introduced. Bone tissue can realize its mechanical function because of the anisotropic microstructure which is derived from cellular activities in response to the physical and chemical environment; the establishment of biomaterials which realize the appropriate anisotropy of regenerated bone is imperative for the medical innovation which enables the functional tissue regeneration.

Journal

  • Zairyo-to-Kankyo

    Zairyo-to-Kankyo 63(5), 290-294, 2014

    Japan Society of Corrosion Engineering

Codes

  • NII Article ID (NAID)
    130004706027
  • Text Lang
    JPN
  • ISSN
    0917-0480
  • Data Source
    J-STAGE 
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