上部消化管内視鏡検査におけるプロポフォール鎮静からの経時的覚醒度と安全性の前向き評価検討 PROSPECTIVE STUDY OF THE EVALUATION OF THE CHRONOLOGICAL CHANGE OF AWAKENING FROM SEDATION WITH PROPOFOL ON UPPER GASTROINTESTINAL ENDOSCOPY AND SAFETY

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【目的】上部消化管内視鏡検査(EGD)におけるプロポフォール鎮静からの覚醒度を経時的に評価し,安全な離院までの必要観察時間を明らかにする.【方法】対象はEGD時に予め定めた投与法によってプロポフォール鎮静を行った104例.平均血圧,動脈血酸素飽和度,握力,視力,Mini Mental State Examination(MMSE),反射神経テストを評価項目とし,検査前と検査終了10分後,60分後を各々比較した.【結果】10分後で有意な低下を認めたのは平均血圧,握力,MMSEであった.60分後では平均血圧は有意な低下を認めたが,10分後に比べると回復傾向であった.握力とMMSEは回復した.【結論】プロポフォール鎮静下のEGDは安全に施行でき,検査終了60分後には平均血圧以外の項目で検査前の状態に回復した.血圧は帰宅基準上問題ない範囲であり,60分後には安全に離院可能と考えられた.

[Purpose] The purposes of this study were to evaluate the degree of awakening from sedation with propofol in patients who underwent upper esophagogastroduodenoscopy (EGD), and clarify the follow-up period required until the patient becomes able to leave the hospital safely. [Methods] The subjects were 104 patients who were sedated with propofol on EGD using the administration method established before this study. The evaluation items consisted of the mean blood pressure, arterial blood oxygen saturation, grip strength, visual acuity, Mini Mental State Examination (MMSE), and reflex nerve test. The results before examination were compared with those at 10 and 60 minutes after completion of the examination. [Results] There were significant decreases in the mean blood pressure, grip strength, and MMSE ten minutes after completion of examination. Although there was a significant decrease in blood pressure 60 minutes after completion of the examination, the value was higher than at 10 minutes. At 60 minutes, the grip strength and MMSE had returned to the pre-examination values. [Conclusion] EGD could be safely performed under sedation with propofol. Sixty minutes after completion of examination, items other than the mean blood pressure had returned to the pre-examination values. The blood pressure met the criterion for leaving the hospital. It may be possible to leave the hospital safely at 60 minutes after EGD.

収録刊行物

  • 日本消化器内視鏡学会雑誌

    日本消化器内視鏡学会雑誌 56(10), 3607-3616, 2014

    Japan Gastroenterological Endoscopy Society

各種コード

  • NII論文ID(NAID)
    130004707298
  • 本文言語コード
    JPN
  • ISSN
    0387-1207
  • データ提供元
    J-STAGE 
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