肝動脈塞栓療法における球状塞栓物質  [in Japanese] Spherical Embolic Agents for Liver Tumor Embolization  [in Japanese]

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Author(s)

    • 大須賀 慶悟 Osuga Keigo
    • 大阪大学大学院医学系研究科 放射線医学講座 Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
    • 前田 登 Maeda Noboru
    • 大阪大学大学院医学系研究科 放射線医学講座 Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
    • 東原 大樹 Higashihara Hiroki
    • 大阪大学大学院医学系研究科 放射線医学講座 Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
    • 田中 会秀 Tanaka Kaishu
    • 大阪大学大学院医学系研究科 放射線医学講座 Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
    • 岸本 健太郎 Kishimoto Kentaro
    • 大阪大学大学院医学系研究科 放射線医学講座 Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
    • 中村 純寿 Nakamura Masahisa
    • 大阪大学大学院医学系研究科 放射線医学講座 Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
    • 小野 祐介 Ono Yusuke
    • 大阪大学大学院医学系研究科 放射線医学講座 Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
    • 中澤 哲郎 Nakazawa Tetsuro
    • 大阪府立成人病センター 放射線診断科 Department of Diagnostic Radiology, Osaka Medical Center for Cancer and Cardiovascular Diseases
    • 富山 憲幸 Tomiyama Noriyuki
    • 大阪大学大学院医学系研究科 放射線医学講座 Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine

Abstract

Recently, three products of calibrated microspheres (Embosphere<SUP>®</SUP>, HepaSphere<SUP>®</SUP>, and DC-Bead<SUP>®</SUP>) have been approved in Japan as embolic agents for hypervascular tumors and arteriovenous malformations. The advantages of these microspheres are that the particles are uniform in size, and easy to inject through a microcatheter. They can travel distally to vessels corresponding to the particle size, and thus, the occlusion level is predictable. Worldwide, the use of these microspheres has been already prevalent in chemoembolization or bland embolization of hepatocellular carcinoma. Two of the approved microspheres (DC-Bead<SUP>®</SUP> and HepaSphere<SUP>®</SUP>) are also applied as drug-eluting microspheres. However, operators should pay attention to some pitfalls in the use of microspheres. Temporary aggregation and redistribution of microspheres may restore the blood flow of a once occluded vessel. The mechanical properties of drug eluting microspheres may alter upon drug loading and release. Therefore, we need to understand the behavior of each microsphere to obtain the optimal embolic effects. It is also important to investigate the true benefits of microspheres or in what clinical or pathological conditions they will improve the safety and efficacy compared to conventional materials.

Journal

  • The Official Journal of the Japanese Society of Interventional Radiology

    The Official Journal of the Japanese Society of Interventional Radiology 28(4), 427-435, 2013

    The Japanese Society of Interventional Radiology

Codes

  • NII Article ID (NAID)
    130004707480
  • Text Lang
    JPN
  • ISSN
    1340-4520
  • Data Source
    J-STAGE 
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