<sup>18</sup>F-AV45（Florbetapir）を用いた脳アミロイドイメージング [in Japanese] Imaging brain amyloid using the radioligand 18F-AV45 (Florbetapir F 18) [in Japanese]
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Alzheimer 病（AD）において脳内に蓄積したアミロイドの描出を<sup>18</sup>F-AV45（Florbetapir）を用いたPET で評価し，軽度認知機能障害（MCI），前頭側頭葉変性症（FTLD）および正常対照（HC）と比較検討を行った．前頭葉，側頭葉，頭頂葉，後頭葉および被殻，視床，橋に関心領域を設定し小脳を対照としたstandardized uptake value ratio（SUVR）を測定し，AD と各疾患で比較した．SUVR は大脳皮質全般でAD において最も高く，MCI はADとHC の中間であった．FTLD では低値であった．HC では白質の集積がやや高かった．<sup>18</sup>F-AV45 を用いることで優れたアミロイドイメージングが得られ，またAD とMCI，FTLD，HC の鑑別にSUVR を用いた半定量法ではアミロイド沈着の評価においてこれまでの報告と同様の結果が得られた．今後症例数を増やした統計学的な検討が必要と考えられた．
We performed <sup>18</sup>F-AV45 positron emission tomography (PET) on 17 patients with Alzheimer disease (AD), 6 patients with mild cognitive impairment (MCI), 6 patients with frontotemporal lobar degeneration (FTLD) and 5 healthy controls (HC). Dynamic PET was performed over approximately 90 min after tracer injection (370 MBq). Subsequently, we constructed time–activity curves. Standardized uptake values (SUVs) and cortex-to-cerebellum SUV ratios (SUVRs) were calculated with regions of interest at the cortical region (frontal, temporal, parietal, and occipital lobes) and other regions (putamen, thalamus, and pons) for all subjects. The SUVRs for patients with AD were greater than those for HC and the SUVRs for patients with MCI were intermediate. The SUVRs were higher for white matter than for gray matter in HC. However, the SUVRs were higher for gray matter than for white matter in patients with AD. The SUVRs in the frontal, parietal, and temporal regions were significantly higher for patients with AD than for HC or those with FTLD. The SUVRs in the frontal and parietal regions were significantly higher for patients with AD than those with MCI. The SUVRs in the occipital regions were not significantly different between patients with AD and other subjects. These results were consistent with those of previous reports on Aβ detection using <sup>18</sup>F-AV45 PET and suggested that <sup>18</sup>F-AV45 PET was probably effective in predicting the risk of onset of AD in patients with MCI, discriminating between AD dementia and non-AD dementia.
- Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism)
Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism) 25(2), 91-96, 2014
The Japanese Society of Cerebral Blood Flow and Metabolism