Imaging brain amyloid using the radioligand 18F-AV45 (Florbetapir F 18)

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  • Kudo Masako
    Division of Neurology and Gerotology, Department of Internal Medicine, Iwate Medical University, Iwate, Japan
  • Yonezawa Hisashi
    Division of Neurology and Gerotology, Department of Internal Medicine, Iwate Medical University, Iwate, Japan
  • Shibata Toshihide
    Division of Neurology and Gerotology, Department of Internal Medicine, Iwate Medical University, Iwate, Japan
  • Obara Satoko
    Division of Neurology and Gerotology, Department of Internal Medicine, Iwate Medical University, Iwate, Japan
  • Takahashi Junko
    Division of Neurology and Gerotology, Department of Internal Medicine, Iwate Medical University, Iwate, Japan
  • Sasaki Toshiaki
    Cyclotron Research Center, Iwate Medical University, Iwate, Japan
  • Terasaki Kazunori
    Cyclotron Research Center, Iwate Medical University, Iwate, Japan
  • Sera Kohichiro
    Cyclotron Research Center, Iwate Medical University, Iwate, Japan
  • Terayama Yasuo
    Division of Neurology and Gerotology, Department of Internal Medicine, Iwate Medical University, Iwate, Japan

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Other Title
  • <sup>18</sup>F-AV45（Florbetapir）を用いた脳アミロイドイメージング

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Abstract

We performed 18F-AV45 positron emission tomography (PET) on 17 patients with Alzheimer disease (AD), 6 patients with mild cognitive impairment (MCI), 6 patients with frontotemporal lobar degeneration (FTLD) and 5 healthy controls (HC). Dynamic PET was performed over approximately 90 min after tracer injection (370 MBq). Subsequently, we constructed time–activity curves. Standardized uptake values (SUVs) and cortex-to-cerebellum SUV ratios (SUVRs) were calculated with regions of interest at the cortical region (frontal, temporal, parietal, and occipital lobes) and other regions (putamen, thalamus, and pons) for all subjects. The SUVRs for patients with AD were greater than those for HC and the SUVRs for patients with MCI were intermediate. The SUVRs were higher for white matter than for gray matter in HC. However, the SUVRs were higher for gray matter than for white matter in patients with AD. The SUVRs in the frontal, parietal, and temporal regions were significantly higher for patients with AD than for HC or those with FTLD. The SUVRs in the frontal and parietal regions were significantly higher for patients with AD than those with MCI. The SUVRs in the occipital regions were not significantly different between patients with AD and other subjects. These results were consistent with those of previous reports on Aβ detection using 18F-AV45 PET and suggested that 18F-AV45 PET was probably effective in predicting the risk of onset of AD in patients with MCI, discriminating between AD dementia and non-AD dementia.

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