本邦における膵移植後患者における悪性腫瘍発生症例の検討 [in Japanese] <i>De novo</i> malignancies after pancreas transplantation in Japan [in Japanese]
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<b>【Background】</b>Long-term immunosuppression is associated with an increased risk of cancer. Especially in pancreas transplantations, more intensive immunosuppression is used than in other organ transplantations because of strong immunogenicity. The aim of this studywas to analyze the incidence of <i>de novo</i> malignancies after pancreas transplantations in Japan.<br><b>【Methods】</b>Posttransplant patients with <i>de novo</i> malignancies were surveyed and characterized.<br><b>【Results】</b>Among 107 cases receiving a pancreas transplantation in Japan from 2001 to 2010, <i>de novo</i> malignancy developed in 9 cases; posttransplant lymphoproliferative disorder (PTLD) in 6, malignant brain tumor in 1, renal cell carcinoma in 1, and colon cancer in 1.<br><b>【Conclusions】</b>We clarified the incidence of <i>de novo</i> malignancies after pancreas transplantation in Japan.
- Japanese Journal of Transplantation
Japanese Journal of Transplantation 49(4-5), 348-352, 2014
The Japan Society for Transplantation