臓器保存における重水の可能性  [in Japanese] Possible cytoprotective actions of heavy water in organ preservation  [in Japanese]

Access this Article

Author(s)

    • 深井 原 Fukai Moto
    • 北海道大学病院消化器外科・一般外科(第一外科) Department of General and Gastrointestinal Surgery, Hokkaido University, School of Medicine
    • 藤堂 省 Todo Satoru
    • 北海道大学大学院医学研究科移植外科学講座 Department of Transplant Surgery, Hokkaido University, Graduate School of Medicine

Abstract

Heavy water, deuterium oxide(D2O), is a stable isotope compound of H2O, causing stabilization of actin and tubulin. D2O inhibits cytosolic calcium overload via plasma membrane channel and ER. D2O stimulates ATP production by augmenting glucose uptake, activities of glycolysis, TCAcylcle, and oxidative phosphorylation in certain experimental models. Further, D2O inhibits organ swelling and damage during cold preservation. Although precise mechanism remains unclear, these properties are considered suitable for the organ preservation. Here we reviewed the possible cytoprotective actions of D2O from the biophysical, biochemical, and clinical viewpoints to enlighten the new insight of organ preservation.

Journal

  • Organ Biology

    Organ Biology 18(1), 92-98, 2011

    The Japan Society for Organ Preservation and Biology

Codes

Page Top