Possible cytoprotective actions of heavy water in organ preservation

DOI
  • Fukai Moto
    Department of General and Gastrointestinal Surgery, Hokkaido University, School of Medicine
  • Todo Satoru
    Department of Transplant Surgery, Hokkaido University, Graduate School of Medicine

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Other Title
  • 臓器保存における重水の可能性

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Abstract

Heavy water, deuterium oxide(D2O), is a stable isotope compound of H2O, causing stabilization of actin and tubulin. D2O inhibits cytosolic calcium overload via plasma membrane channel and ER. D2O stimulates ATP production by augmenting glucose uptake, activities of glycolysis, TCAcylcle, and oxidative phosphorylation in certain experimental models. Further, D2O inhibits organ swelling and damage during cold preservation. Although precise mechanism remains unclear, these properties are considered suitable for the organ preservation. Here we reviewed the possible cytoprotective actions of D2O from the biophysical, biochemical, and clinical viewpoints to enlighten the new insight of organ preservation.

Journal

  • Organ Biology

    Organ Biology 18 (1), 92-98, 2011

    The Japan Society for Organ Preservation and Biology

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