Cleavage of carbohydrates in ABO blood group antigens

• Kobayashi Takaaki

  Nagoya University School of Medicine, Department of Applied Immunology

Bibliographic Information

Other Title

• ABO血液型糖鎖抗原の切断

Abstract

After the introduction of desensitization protocol, the outcome of ABO incompatible renal transplantation(Tx)is now comparable to that of ABO identical/compatible Tx. However, since severe antibody-mediated rejection has been observed in some cases, the development of more safe and efficient method is desirable. Our attention has been directed towards enzymatic digestion of A/B carbohydrate antigens in the graft. In vivo and ex vivo experiment revealed that over 90% of A/B antigens expressed in endothelial cells of the baboon graft could be successfully removed. Elucidation of accommodation mechanisms through analysis of complement, inflammation and coagulation, and signal pathway in details would also be essential for further improvement of organ Tx.

Journal

• Organ Biology

  Organ Biology 18 (1), 116-120, 2011

  The Japan Society for Organ Preservation and Biology

Keywords

• endo-beta-galact osidase
• ABO incompatible transplantation
• blood type A/B antigen

Details

• CRID: 1390001205514138624
• NII Article ID: 130004709993
• DOI: 10.11378/organbio.18.116
• COI: 1:CAS:528:DC%2BC3MXhtFSgsL%2FP
• ISSN: 21880204
• ISSN: 13405152
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed