移植臓器の非侵襲的モニタリング法の開発  [in Japanese] Development ofa novel non-invasive monitoring system for organ/cell transplantation  [in Japanese]

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Author(s)

    • 尾崎 倫孝 Ozaki Michitaka
    • 北海道大学大学院医学研究科分子制御外科学講座 Hokkaido University School Medicine, Department of Molecular Surgery
    • 芳賀 早苗 Haga Sanae
    • 東京大学大学院理学系研究科化学専攻|日本学術振興会特別研究員 The University of Tokyo, Department of Chemistry|The Japan Society for the Promotion of Science(JSPS)
    • 森田 直樹 Morita Naoki
    • 産業技術総合研究所生物プロセス研究部門 National Institute of Advanced Industrial Science and Technology(AIST), Bioproduction Research Institute
    • 深井 原 Fukai Moto
    • 北海道大学病院消化器外科・一般外科(第一外科) Hokkaido University School Medicine, Department of General and Gastrointestinal Surgery
    • 藤堂 省 Todo Satoru
    • 北海道大学大学院医学研究科移植外科学講座 Hokkaido University School Medicine, Department of Organ Transplantation
    • 近江谷 克裕 Ohmiya Yoshihiro
    • 産業技術総合研究所生物プロセス研究部門 National Institute of Advanced Industrial Science and Technology(AIST), Bioproduction Research Institute

Abstract

In order to develop an effective organ/cell preservation solution and to monitor graft function continuously and non-invasively, an innovative imaging technology to visualize cell/organ function is required. Recently, we developed molecular probes to visualize redox states and cellular stresses,and cellular antigens in deeper lesions of the organ. In the hepatic ischemia/reperfusion model of mice, we successfully imaged liver oxidative stress and apoptosis(by caspase-3 activity)noninvasively and chronologically in a single mouse. We are also trying to develop new tools to visualize ER stress and cellular antigens in deeper lesions. These tools will definitely provide a new avenue toward cell/organ transplantation in the future.

Journal

  • Organ Biology

    Organ Biology 18(1), 134-140, 2011

    The Japan Society for Organ Preservation and Biology

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