移植臓器の非侵襲的モニタリング法の開発 Development ofa novel non-invasive monitoring system for organ/cell transplantation

In order to develop an effective organ/cell preservation solution and to monitor graft function continuously and non-invasively, an innovative imaging technology to visualize cell/organ function is required. Recently, we developed molecular probes to visualize redox states and cellular stresses,and cellular antigens in deeper lesions of the organ. In the hepatic ischemia/reperfusion model of mice, we successfully imaged liver oxidative stress and apoptosis(by caspase-3 activity)noninvasively and chronologically in a single mouse. We are also trying to develop new tools to visualize ER stress and cellular antigens in deeper lesions. These tools will definitely provide a new avenue toward cell/organ transplantation in the future.