Development ofa novel non-invasive monitoring system for organ/cell transplantation
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- Ozaki Michitaka
- Hokkaido University School Medicine, Department of Molecular Surgery
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- Haga Sanae
- The University of Tokyo, Department of Chemistry The Japan Society for the Promotion of Science(JSPS)
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- Morita Naoki
- National Institute of Advanced Industrial Science and Technology(AIST), Bioproduction Research Institute
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- Fukai Moto
- Hokkaido University School Medicine, Department of General and Gastrointestinal Surgery
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- Todo Satoru
- Hokkaido University School Medicine, Department of Organ Transplantation
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- Ozawa Takeaki
- The University of Tokyo, Department of Chemistry
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- Ohmiya Yoshihiro
- National Institute of Advanced Industrial Science and Technology(AIST), Bioproduction Research Institute
Bibliographic Information
- Other Title
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- 移植臓器の非侵襲的モニタリング法の開発
Abstract
In order to develop an effective organ/cell preservation solution and to monitor graft function continuously and non-invasively, an innovative imaging technology to visualize cell/organ function is required. Recently, we developed molecular probes to visualize redox states and cellular stresses,and cellular antigens in deeper lesions of the organ. In the hepatic ischemia/reperfusion model of mice, we successfully imaged liver oxidative stress and apoptosis(by caspase-3 activity)noninvasively and chronologically in a single mouse. We are also trying to develop new tools to visualize ER stress and cellular antigens in deeper lesions. These tools will definitely provide a new avenue toward cell/organ transplantation in the future.
Journal
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- Organ Biology
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Organ Biology 18 (1), 134-140, 2011
The Japan Society for Organ Preservation and Biology
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Details 詳細情報について
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- CRID
- 1390001205514140928
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- NII Article ID
- 130004709996
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- COI
- 1:CAS:528:DC%2BC3MXhtFSgsL%2FJ
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- ISSN
- 21880204
- 13405152
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed