Associations between Co-Detected Respiratory Viruses in Children with Acute Respiratory Infections

• Kaida Atsushi

  Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences

• Kubo Hideyuki

  Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences

• Takakura Koh-ichi

  Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences

• Sekiguchi Jun-ichiro

  Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences

• Yamamoto Seiji P.

  Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences

• Kohdera Urara

  Nakano Children's Hospital

• Togawa Masao

  Osaka City General Hospital

• Amo Kiyoko

  Osaka City General Hospital

• Shiomi Masashi

  Aizenbashi Hospital

• Ohyama Minori

  Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences

• Goto Kaoru

  Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences

• Hase Atsushi

  Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences

• Kageyama Tsutomu

  Influenza Virus Research Center, National Institute of Infectious Diseases

• Iritani Nobuhiro

  Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences

Bibliographic Information

Other Title

• Associations between co‐infecting respiratory viruses in children with acute respiratory infections

Abstract

Viruses are the major etiological agents of acute respiratory infections (ARIs) in young children. Although respiratory virus co-detections are common, analysis of combinations of co-detected viruses has never been conducted in Japan. Nineteen respiratory viruses or subtypes were surveyed using multiplex real-time PCR on 1,044 pediatric (patient age < 6 years) ARI specimens collected in Osaka City, Japan between January 2010 and December 2011. In total, 891 specimens (85.3%) were virus positive (1,414 viruses were detected), and 388 of the virus-positive specimens (43.5%, 388/891) were positive for multiple viruses. The ratio of multiple/total respiratory virus-positive specimens was high in children aged 0–35 months. Statistical analyses revealed that human bocavirus 1 and human adenovirus were synchronously co-detected. On the other hand, co-detections of human parainfluenza virus type 1 (HPIV-1) with HPIV-3, HPIV-3 with human metapneumovirus (hMPV), hMPV with respiratory syncytial virus A (RSV A), hMPV with influenza virus A (H1N1) 2009 (FLUA (H1N1) 2009), RSV A with RSV B, and human rhinovirus and FLUA (H1N1) 2009 were exclusive. These results suggest that young children (<3 years) are highly susceptible to respiratory viruses, and some combinations of viruses are synchronously or exclusively co-detected.

Journal

• Japanese Journal of Infectious Diseases

  Japanese Journal of Infectious Diseases 67 (6), 469-475, 2014

  National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

Keywords

• respiratory virus
• co-detection
• young children
• statistical analysis
• Japan

Details

• CRID: 1390001206241518720
• NII Article ID: 130004712740
• NII Book ID: AA1132885X
• DOI: 10.7883/yoken.67.469
• ISSN: 18842836
• ISSN: 13446304
• NDL BIB ID: 025937900
• PubMed: 25410563
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025937900
• Web Site: https://search.jamas.or.jp/link/ui/2015279334
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed