Effects of Repeated Intravenous Administration of Dextrans,Water-soluble Macromolecules, in Rats

• Kitazawa Ikue

  Central Research Laboratories, Seikagaku Corporation

• Ito Shino

  Central Research Laboratories, Seikagaku Corporation

• Kagawa Yusuke

  Central Research Laboratories, Seikagaku Corporation

• Suehiro-Narita Miki

  Central Research Laboratories, Seikagaku Corporation

• Hashizume Naoto

  Central Research Laboratories, Seikagaku Corporation

• Minamisawa Yuka

  Central Research Laboratories, Seikagaku Corporation

• Nii Aisuke

  Central Research Laboratories, Seikagaku Corporation

• Kawakami Akio

  Central Research Laboratories, Seikagaku Corporation

• Nakajima Shinichi

  Central Research Laboratories, Seikagaku Corporation

Bibliographic Information

Other Title

• Effects of reported intravenous administration of dextrans, water-soluble macromolecules, in rats

Abstract

We investigated the influence of repeated intravenous administration of dextrans (DEXs) to rats. Seven-week-old Sprague Dawley rats (6 males/group) were given intravenously 10% saline solutions of dextrans (DEXs), 40 kDa or 200–300 kDa, at a dose level of 5 mL/kg/day for 28 days and they were examined histopathologically. Another group (3 males/group) was administered saline in a similar manner and served as the control. Histopathological changes indicating accumulation of DEXs in the mononuclear phagocyte system (MPS) and the liver were noted in the treated groups. The incidence and severity of the findings were molecular weight-dependent, except for the lungs. These results are considered useful in interpreting data from preclinical studies, in which DEXs or their derivatives are administered as test or control substances.

Journal

• Journal of Toxicologic Pathology

  Journal of Toxicologic Pathology 27 (3+4), 231-234, 2014

  JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY

Keywords

• macromolecular substances
• intravenous administration
• mononuclear phagocyte system

Details

• CRID: 1390282679392883328
• NII Article ID: 130004713009
• NII Book ID: AN10232280
• DOI: 10.1293/tox.2013-0067
• ISSN: 1881915X
• ISSN: 09149198
• NDL BIB ID: 025899974
• PubMed: 25378808
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025899974
• Web Site: https://www.jstage.jst.go.jp/article/tox/27/3+4/27_2013-0067/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015248512
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed