Effects of Repeated Intravenous Administration of Dextrans,Water-soluble Macromolecules, in Rats

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Author(s)

Abstract

We investigated the influence of repeated intravenous administration of dextrans (DEXs) to rats. Seven-week-old Sprague Dawley rats (6 males/group) were given intravenously 10% saline solutions of dextrans (DEXs), 40 kDa or 200–300 kDa, at a dose level of 5 mL/kg/day for 28 days and they were examined histopathologically. Another group (3 males/group) was administered saline in a similar manner and served as the control. Histopathological changes indicating accumulation of DEXs in the mononuclear phagocyte system (MPS) and the liver were noted in the treated groups. The incidence and severity of the findings were molecular weight-dependent, except for the lungs. These results are considered useful in interpreting data from preclinical studies, in which DEXs or their derivatives are administered as test or control substances.

Journal

  • Journal of Toxicologic Pathology

    Journal of Toxicologic Pathology 27(3+4), 231-234, 2014

    JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY

Codes

  • NII Article ID (NAID)
    130004713009
  • NII NACSIS-CAT ID (NCID)
    AN10232280
  • Text Lang
    ENG
  • ISSN
    0914-9198
  • NDL Article ID
    025899974
  • NDL Call No.
    Z19-2431
  • Data Source
    NDL  J-STAGE 
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