Toxicokinetics of perfluoroalkyl carboxylates with different carbon chain lengths in mice and humans
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- Fujii Yukiko
- Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine
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- Niisoe Tamon
- Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine
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- Harada Kouji H.
- Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine
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- Uemoto Shinji
- Department of Hepatobiliary, Pancreas and Transplant Surgery, Kyoto University Graduate School of Medicine
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- Ogura Yasuhiro
- Transplantation Surgery, Nagoya University Hospital
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- Takenaka Katsunobu
- Department of Neurosurgery, Takayama Red Cross Hospital
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- Koizumi Akio
- Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine
書誌事項
- タイトル別名
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- Toxicokinetics of perfluoroalkyl carboxylic acids with different carbon chain lengths in mice and humans
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Objectives: Perfluoroalkyl carboxylic acids (PFCAs) consist of analogs with various carbon chain lengths. Their toxicokinetics have remained unexplored except in the case of perfluorooctanoic acid (8 carbon chemicals). This study aimed to investigate the toxicokinetics of PFCAs with six to fourteen carbon atoms (C6 to C14) in mice and humans. Methods: We applied a two-compartment model to mice administered PFCAs intravenously or by gavage. The time courses of the serum concentration and tissue distribution and elimination were evaluated for 24 hours after treatment. For human samples, urine from healthy volunteers, bile from patients who underwent biliary drainage, and cerebral spinal fluid (CSF) from brain drainage were collected. Results: The mouse experiment showed that short-chained PFCAs (C6 and C7) were rapidly eliminated in the urine, whereas long-chain PFCAs (C8 to C14) accumulated in the liver and were excreted slowly in feces. Urinary clearance of PFCAs in humans also decreased with increasing alkyl chain lengths, while biliary clearances increased. C9 to C10 had the smallest total clearance for both mice and humans. However, disparities existed in the magnitude of the total clearance between mice and humans. A slightly higher partition ratio (brain/serum) was observed for long-chained PFCAs in mice, but this was not observed in the corresponding partition ratio in humans (CSF/serum). Conclusions: The large sequestration volumes of PFCAs in the liver seem to be attributable to the liver's large binding capacity in both species. This will be useful in evaluating PFCA bioaccumulation in other species.(J Occup Health 2015; 57: 1–12)
収録刊行物
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- journal of Occupational Health
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journal of Occupational Health 57 (1), 1-12, 2015
公益社団法人 日本産業衛生学会
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詳細情報 詳細情報について
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- CRID
- 1390282679432365056
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- NII論文ID
- 40020352278
- 130004713080
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- NII書誌ID
- AA11090645
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- ISSN
- 13489585
- 13419145
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- NDL書誌ID
- 026085966
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- PubMed
- 25422127
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 使用不可