Cineventriculographic Analysis of Left Ventricular Dynamics during Sustained Handgrip Exercise

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  • MIYAZAWA KOZUI
    Department of Clinical Laboratory, Yamagata University School of Medicine
  • HONNA TAKAO
    Department of Internal Medicine, Tohoku University School of Medicine
  • HANEDA TAKASHI
    Department of Internal Medicine, Tohoku University School of Medicine
  • ARAI TORU
    Department of Internal Medicine, Tohoku University School of Medicine
  • NAKAJIMA TOSHIYUKI
    Department of Internal Medicine, Tohoku University School of Medicine
  • MIURA TAKUJI
    Department of Internal Medicine, Tohoku University School of Medicine
  • KANAZAWA MASAHARU
    Department of Internal Medicine, Tohoku University School of Medicine
  • ONODERA SACHIO
    Department of Internal Medicine, Tohoku University School of Medicine

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タイトル別名
  • Cineventriculographic Analysis of Left

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In order to evaluate the effect of handgrip on left ventricular dynamics, cineventriculography was performed in 16 patients with heart disease and 5 normal subjects at 30% of maximal voluntary contraction. No patient had ventriculographic evidence of asynergy or valve regurgitation. During exercise, left ventricular end-diastolic volume (LVEDV) insignificantly increased, left ventricular end-systolic volume (LVESV) decreased, and hence stroke volume (SV) and ejection fraction (EF) rose in the normal group, while in the patient group a similar change in LVEDV was associated with increased LVESV, resulting in unchanged SV and decreased EF. It is notable that during exercise LVEDV increased in both groups, despite a shortened diastolic filling period. Mean velocity of fiber shortening (mean VCF) increased in the normal group and remained unchanged in the patient group. The changes in mean VCF, during exercise were correlated with the alterations in SV and EF (r=0.46, p<0.05 and r=0.90, p<0.001, respectively). These data signify that an increased afterload induced by handgrip leads to an enhanced left ventricular myocardial contraction in addition to an increase in preload in the normal group, while the Frank-Starling mechanism is mainly utilized in the patient group.

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