Overview of Model-Based Dose-Finding Methods for Combinations of Two Agents in Phase I Oncology Trials

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  • Hirakawa Akihiro
    Center for Advanced Medicine and Clinical Research, Nagoya University Graduate School of Medicine
  • Matsui Shigeyuki
    Department of Biostatistics, Nagoya University Graduate School of Medicine

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  • がん第 I 相試験における 2 剤併用療法の用量探索法：最近の展開
  • ガン ダイ Ⅰ ソウ シケン ニ オケル 2ザイ ヘイヨウ リョウホウ ノ ヨウリョウ タンサクホウ : サイキン ノ テンカイ

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Abstract

We discuss toxicity-based dose-finding methods for two-agent combinations in phase I oncology trials. We focus on the four dose-finding methods recently developed, the methods based on 1) a copula-type model, 2) a hierarchical Bayesian model, 3) continual reassessment method with partial ordering (POCRM), and 4) a shrinkage logistic model. We summarize the characteristic of each method and compare the performance among them through simulation studies. In the simulation studies, we examined recommendation rates (RDs) for both true maximum tolerated dose combinations (MTDCs) and unacceptable toxicity dose combinations (UTDCs) under 12 scenarios with 3 × 3, 4 × 4, 2 × 4, and 3 × 5 dose combination matrices. Simulation studies demonstrated that the POCRM and method using the shrinkage logistic model outperformed the other two methods in terms of recommending true MTDCs. The RDs for the UTDCs in the method using the shrinkage logistic model were lower than the other three methods.

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