Rapid Desensitization with Autologous Sweat in Cholinergic Urticaria

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Author(s)

    • Kozaru Takeshi
    • Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine
    • Fukunaga Atsushi
    • Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine
    • Taguchi Kumiko
    • Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine
    • Ogura Kanako
    • Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine
    • Nagano Tohru
    • Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine
    • Oka Masahiro
    • Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine
    • Horikawa Tatsuya
    • Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine
    • Nishigori Chikako
    • Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine

Abstract

<b>Background:</b> The majority of patients with cholinergic urticaria presents with strong hypersensitivity to autologous sweat. Patients with severe cholinergic urticaria are frequently resistant to H<sub>1</sub> antagonists which are used in conventional therapies for various types of urticaria. It has been reported that desensitization using partially purified sweat antigen was effective in a patient with cholinergic urticaria.<br> <b>Methods:</b> The aim of this study is to determine the usefulness of rapid desensitization with autologous sweat in severe cholinergic urticaria, because rapid desensitization has proven to be a quick and effective immunotherapy for allergies to various allergens. Six patients with severe cholinergic urticaria who are resistant to H<sub>1</sub> antagonists and have sweat hypersensitivity were enrolled in a rapid desensitization protocol.<br> <b>Results:</b> In all six patients, the responses for skin tests with autologous sweat were attenuated after rapid desensitization with autologous sweat. Two of the three cholinergic urticaria patients showed reduced histamine release with autologous sweat after the rapid desensitization with autologous sweat. Further, the rapid desensitization and subsequent maintenance treatment reduced the symptoms in five of the six patients.<br> <b>Conclusions:</b> This study provides evidence that rapid desensitization with autologous sweat is beneficial for treating cholinergic urticaria patients resistant to conventional therapy who have sweat hypersensitivity.<br>

Journal

  • Allergology International

    Allergology International 60(3), 277-281, 2011

    Japanese Society of Allergology

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