Cimetidine Enhances Antigen-Specific IgE and Th2 Cytokine Production

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Author(s)

    • Arae Ken
    • Department of Immunology, Faculty of Health Sciences, Kyorin University|Department of Allergy and Immunology, National Research Institute for Child Health and Development
    • Oboki Keisuke
    • Department of Allergy and Immunology, National Research Institute for Child Health and Development
    • Ohno Tatsukuni
    • Department of Allergy and Immunology, National Research Institute for Child Health and Development
    • Hirata Masako
    • Department of Immunology, Faculty of Health Sciences, Kyorin University
    • Nakae Susumu
    • Frontier Research Initiative, The Institute of Medical Science, The University of Tokyo
    • Taguchi Haruhiko
    • Department of Immunology, Faculty of Health Sciences, Kyorin University
    • Saito Hirohisa
    • Department of Allergy and Immunology, National Research Institute for Child Health and Development
    • Nakajima Toshiharu
    • Department of Allergy and Immunology, National Research Institute for Child Health and Development|Department of Immunology, Yokohama College of Pharmacy

Abstract

<b>Background:</b> Treatment with anti-ulcer drugs has been shown to enhance IgE production against food antigens. However, little is known about the immunological effects of cimetidine, a histamine receptor type 2 (H2R) antagonist that is widely used as an anti-ulcer drug, in allergy. Therefore, the present study investigated the role of cimetidine in Th2 immune responses in mice.<br> <b>Methods:</b> BALB/c mice were immunized intraperitoneally with ovalbumin (OVA) with and without cimetidine. The levels of cytokines in supernatants of spleen cells cultured in the presence of OVA for 4 days and the levels of total and OVA-specific IgG<sub>1</sub>, IgG<sub>2a</sub> and/or IgE in sera from these mice were determined by ELISA.<br> <b>Results:</b> Administration of cimetidine to OVA-sensitized BALB/c mice promoted Th2 cytokine secretion by OVA-stimulated spleen cells <i>in vitro</i> and increased serum levels of OVA-specific IgE, IgG<sub>1</sub> and IgG<sub>2a</sub>.<br> <b>Conclusions:</b> These results indicate that cimetidine can enhance Th2 responses, suggesting that cimetidine may contribute to IgE production in allergies.<br>

Journal

  • Allergology International

    Allergology International 60(3), 339-344, 2011

    Japanese Society of Allergology

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