地域・職域別にみた血清総コレステロール値の動向と循環器疾患との関連 Studies on the Relationship between the Trend of Serum Total Cholesterol Level and the Incidence of Cerebro-Cardio-Vascular Diseases Based on the Follow-up Studies in Akita and Osaka—with a Special Reference to the Optimal Serum Total Cholesterol Level Preventing both Cerebral Hemorrhage and. Coronary Heart Disease
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We have already reported from our epidemiological studies that serum total cholesterol is a negative risk factor of cerebral hemorrhage and is a positive risk factor of coronary heart disease.<br>In this study, we tried to find the optimal serum total cholesterol level preventing both cerebral hemorrhage and coronary heart disease.<br>To find the lower limit of optimal serum total cholesterol level, we saw the relationship between serum total cholesterol level and cerebral hemorrhage incidence in our Akita cohort. As the result, the incidence of cerebral hemorrhage was markedly higher in those whose serum total cholesterol was less than 140mg/dl compared with those whose cholesterol levels were higher than that.<br>On the other hand, we also saw the relationship between serum total cholesterol and coronary heart disease in our Osaka cohort of employees in order to find the upper limit of optimal serum total cholesterol level. From this study, we have found that the incidence of coronary heart disease was markedly higher in those whose serum total cholesterol levels were more than 200mg/dl than in those of cholesterol level less than that.<br>From these results, we conclude that the optimal level of serum total cholesterol is 140-200mg/dl for the prevention of both cerebral hemorrhage and coronary heart disease.
- Journal of Atherosclerosis and Thrombosis
Journal of Atherosclerosis and Thrombosis 15(5), 1115-1123, 1987
Japan Atherosclerosis Society