自閉症における表情模倣時の脳血流変化:—NIRSによる検討—  [in Japanese] Hemodynamic activities in children with autism while imitating emotional facial expressions: a near-infrared spectroscopy study  [in Japanese]

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Author(s)

    • 森 健治 Mori Kenji
    • 徳島大学大学院ヘルスバイオサイエンス研究部子どもの保健・看護学分野 Departments of Child Health & Nursing, Institute of Health Biosciences, University of Tokushima Graduate School
    • 森 達夫 Mori Tatsuo
    • 徳島大学大学院ヘルスバイオサイエンス研究部小児医学分野 Departments of CPediatrics, Institute of Health Biosciences, University of Tokushima Graduate School
    • 郷司 彩 Goji Aya
    • 徳島大学大学院ヘルスバイオサイエンス研究部小児医学分野 Departments of CPediatrics, Institute of Health Biosciences, University of Tokushima Graduate School
    • 伊藤 弘道 Ito Hiromichi
    • 徳島大学大学院ヘルスバイオサイエンス研究部小児医学分野 Departments of CPediatrics, Institute of Health Biosciences, University of Tokushima Graduate School
    • 東田 好広 Toda Yoshihiro
    • 徳島大学大学院ヘルスバイオサイエンス研究部小児医学分野 Departments of CPediatrics, Institute of Health Biosciences, University of Tokushima Graduate School
    • 藤井 笑子 Fujii Emiko
    • 徳島大学大学院ヘルスバイオサイエンス研究部小児医学分野 Departments of CPediatrics, Institute of Health Biosciences, University of Tokushima Graduate School
    • 宮崎 雅仁 Miyazaki Masahito
    • 徳島大学大学院ヘルスバイオサイエンス研究部小児医学分野 Departments of CPediatrics, Institute of Health Biosciences, University of Tokushima Graduate School
    • 原田 雅史 Harada Masafumi
    • 徳島大学大学院ヘルスバイオサイエンス研究部放射線科学分野 Departments of CRadiology, Institute of Health Biosciences, University of Tokushima Graduate School
    • 香美 祥二 Kagami Shoji
    • 徳島大学大学院ヘルスバイオサイエンス研究部小児医学分野 Departments of CPediatrics, Institute of Health Biosciences, University of Tokushima Graduate School

Abstract

 【目的】近赤外線スペクトロスコピー (NIRS) を用い, 顔表情の模倣課題を施行中の前頭葉活動について, 自閉症と定型発達の小児例で比較検討する. 【方法】対象は定型発達の男児10例, 知的障害を有さない自閉性障害の男児10例. NIRS測定のため左右前頭部にそれぞれ17チャンネルのプローブを装着した. 【結果】自閉症群において初回検査時, 両側下前頭回弁蓋部 (Broca野) での酸素化ヘモグロビン (oxy-Hb) 濃度の上昇は, 定型発達児に比べ有意に低かったが, 同じ課題を複数回練習してから, 再度, NIRSを施行したところ, 同部でoxy-Hb濃度の有意な上昇が認められた. 自閉症群におけるoxy-Hb濃度の変化量と感情ラベリング成績の間には正の相関関係が認められた. 【結論】自閉症においても模倣運動を繰り返すことによりミラーニューロンを賦活できる可能性が示唆された.

  <i><b>Objective:</b></i> To examine the hemodynamic activities in the frontal lobe, children with autistic disorder and matched controls underwent near-infrared spectroscopy (NIRS) while imitating emotional facial expressions. <i><b>Methods:</b></i> The subjects consisted of 10 boys with autistic disorder without mental retardation (9~14 years) and 10 normally developing boys (9~14 years). The concentrations of oxyhemoglobin (oxy-Hb) were measured with frontal probes using a 34-channel NIRS machine while the subjects imitated emotional facial expressions. <i><b>Results:</b></i> The increments in the concentration of oxy-Hb in the pars opercularis of the inferior frontal gyrus in autistic subjects were significantly lower than those in the controls. However, the concentrations of oxy-Hb in this area were significantly elevated in autistic subjects after they were trained to imitate emotional facial expressions. The increments in the concentration of oxy-Hb in this area in autistic subjects were positively correlated with the scores on a test of labeling emotional facial expressions. <i><b>Conclusions:</b></i> The pars opercularis of the inferior frontal gyrus is an important component of the mirror neuron system. The present results suggest that mirror neurons could be activated by repeated imitation in children with autistic disorder.

Journal

  • NO TO HATTATSU

    NO TO HATTATSU 46(4), 281-286, 2014

    The Japanese Society of Child Neurology

Codes

  • NII Article ID (NAID)
    130004728676
  • Text Lang
    JPN
  • ISSN
    0029-0831
  • Data Source
    J-STAGE 
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