Gold Nanoparticles Modified with Double-stranded DNA for Analytical Applications

• TAKARADA Tohru

  Bioengineering Laboratory, RIKEN

• MAEDA Mizuo

  Bioengineering Laboratory, RIKEN

Bibliographic Information

Other Title

• DNA二重らせん担持金ナノ粒子を用いる分析化学
• DNAニジュウラセン タンモチガネ ナノ リュウシ オ モチイル ブンセキ カガク

Abstract

Gold naoparticles densely functionalized with a DNA duplex undergo rapid and spontaneous aggregation in a medium of relatively high ionic strength. This non-crosslinking aggregation occurs irrespective of the particle size and the DNA length, while it exhibits both greater temperature- and salt concentration-dependence than that of DNA duplex formation. Interestingly, no aggregation takes place under the same conditions when the DNA duplex has a single-base mismatch at the distal end, which is located at the outermost surface of the particle. In this review, we describe applications of the DNA-carrying gold nanoparticles to gene diagnosis and chemical sensing, with emphasis placed on some attempts to improve the sensitivity.

Journal

• BUNSEKI KAGAKU

  BUNSEKI KAGAKU 64 (1), 15-23, 2015

  The Japan Society for Analytical Chemistry

Keywords

• gold
• nanoparticle
• DNA
• aggregation
• biosensing

Details

• CRID: 1390001204661483264
• NII Article ID: 130004732533
• NII Book ID: AN00222633
• DOI: 10.2116/bunsekikagaku.64.15
• NDL BIB ID: 026052106
• ISSN: 05251931
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026052106
• Web Site: https://www.jstage.jst.go.jp/article/bunsekikagaku/64/1/64_15/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015111773
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed