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- 巴山 忠
- 福岡大学薬学部
書誌事項
- タイトル別名
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- Highly Selective Analysis of Biogenic-related Compounds Utilizing Fluorous Chemistry
- Symposium Review フルオラスケミストリーを駆使した生体関連物質の高選択的分析
- Symposium Review フルオラスケミストリー オ クシ シタ セイタイ カンレン ブッシツ ノ コウセンタクテキ ブンセキ
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抄録
Perfluoroalkyl-containing compounds are highly fluorous, meaning that they have a remarkable affinity for one another and effectively exclude non-fluorous species. Utilizing this unique property, we have developed a fluorous derivatization with a liquid chromatographic analysis method for highly selective analysis of target analytes. Although most previous methods focused on extremely sensitive detection-oriented derivatization, the fluorous derivatization method involves highly specific separation for analytes. This method includes perfluoroalkylation of analytes with a fluorous reagent, and separation of the derivatives using a perfluoroalkyl-modified stationary phase LC column. The derivatives can be selectively retained on the fluorous-phase LC column, whereas the non-fluorous derivatives are poorly retained under the same separation conditions. The combination of this method with LC-tandem mass spectrometry (MS/MS) is very useful for complex biological sample analysis, because matrix-induced suppression effects, which are a common problem in LC-MS/MS analysis arising from components of a biological endogenous matrix, have not been observed. We have successfully applied this method to precise and accurate LC-MS/MS analysis of some biogenic compounds, such as sialic acids and biogenic amines, in complex biological samples.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 135 (2), 205-212, 2015-02-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206126527616
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- NII論文ID
- 130004756499
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 026075437
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- PubMed
- 25747214
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可