Clinical Implications of Pre-Operative Rapid BRAF Analysis for Papillary Thyroid Cancer
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- KUMAGAI Atsushi
- Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences Department of Public Health and Environment, World Health Organization
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- NAMBA Hiroyuki
- Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences
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- AKANOV Zhanay
- Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences
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- SAENKO Vladimir A.
- International Health and Radiation Research, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences
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- MEIRMANOV Serik
- Tissue and Histopathology Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences
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- OHTSURU Akira
- Takashi Nagai Memorial International Hibakusha Medical Center, Nagasaki University Hospital
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- YANO Hiroshi
- Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences
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- MAEDA Shigeto
- Division of Endocrine Surgery, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences
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- ANAMI Masanobu
- Department of Clinical Pathology, Nagasaki University Hospital
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- HAYASHI Tomayoshi
- Department of Clinical Pathology, Nagasaki University Hospital
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- ITO Masahiro
- Department of Pathology, National Nagasaki Medical Center
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- SAGANDIKOVA Sagadat
- Semipalatinsk Diagnostic Center
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- ELEUBAEVA Zhanar
- Semipalatinsk Regional Oncology Center
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- MUSSINOV Daniyal
- Semipalatinsk Regional Oncology Center Semipalatinsk State Medical Academy
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- ESPENBETOVA Maira
- Semipalatinsk State Medical Academy
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- YAMASHITA Shunichi
- Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences Department of Public Health and Environment, World Health Organization International Health and Radiation Research, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences Takashi Nagai Memorial International Hibakusha Medical Center, Nagasaki University Hospital
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The activating point mutation of the BRAF gene, BRAFT1799A, is the most common and specific genetic alteration in adult papillary thyroid carcinoma (PTC) and a possible marker of malignant potential of PTC. We have applied the PCR-RFLP method using fine-needle aspiration biopsy samples not only to our clinical practice but also to the international medical assistance effort around the Semipalatinsk Nuclear Testing Site in Kazakhstan. Seventy-seven cases (100 nodules) from Japan and 131 cases (137 nodules) from Kazakhstan were examined. There were 14 Japanese and 76 Kazakhstani cases of cytological malignant tumors from the examined samples. We detected 12 (85.7% of PTC) and 19 (25% of PTC) cases with BRAFT1799A among the Japanese and Kazakhstani cases, respectively. Of these cases, we found mutations in one cytologically "suspicious" case and even in two pathologically "benign" cases (after surgery in Kazakhstan). All of the BRAF mutation-positive cases, including those three, were confirmed as PTC by careful pathological examination, including immunohistochemical analysis. In summary, our PCR-RFLP method for BRAFT1799A detection using FNAB samples is useful not only for preoperative diagnosis of PTC but also as a complementary diagnostic tool for accurate pathological diagnosis, even after surgery.<br>
収録刊行物
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- Endocrine Journal
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Endocrine Journal 54 (3), 399-405, 2007
一般社団法人 日本内分泌学会
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詳細情報 詳細情報について
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- CRID
- 1390282681277331712
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- NII論文ID
- 80018411413
- 130004770035
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- ISSN
- 13484540
- 09188959
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可