顎顔面領域における骨・軟骨再生に関する基礎および臨床研究 Basic and clinical research on bone and cartilage regenerative medicine in the oral and maxillofacial region
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Recently, there have been remarkable advances in regenerative medicine, and almost all disorders in the oral and maxillofacial region could be research targets of regenerative medicine. Meanwhile, treatments in this region have been well established using biomaterials, prostheses and microsurgery. Therefore, in order to be used instead of such conventional approaches, regenerative medicine should take a less invasive, more effective approach. In this report, we present our basic and clinical research on bone and cartilage regenerative medicine in the oral and maxillofacial region.<br>Regarding bone regenerative medicine, we have tried to develop artificial bone that maximizes bone formation at the transplanted site, but that would be subsequently replaced by autologous bone. We have made custom-made artificial bone (CT-Bone) using α-TCP particles and an ink-jet printer, and have conducted clinical research and trials on 30 patients.<br>Present protocols of autologous chondrocyte transplantation mostly utilize chondrocytes suspended in solution or gel, and thus the regenerated cartilage may fail biologically and biophysically. To develop tissue-engineered cartilage with proper 3D morphology and mechanical strength, we have optimized the culture medium of chondrocytes and scaffold. Following a preclinical study confirming efficacy and safety, our protocol has been approved by the Institutional Review Board as well as the Ministry of Health, Labour and Welfare, Japan. We have conducted clinical research for 3 patients with nasal deformity in cleft lip and palate, and are now starting multicenter clinical research. Also, we are preparing for investigator-initiated clinical trials of tissue-engineered trachea for reconstruction of trachea.
- Journal of The Japanese Stomatological Society
Journal of The Japanese Stomatological Society 63(2), 207-215, 2014
Japanese Stomatological Society