The Network Structure and the Drug Release Characteristics of Agar Gel and Xanthan Gum-Locust Bean Gum Complex Gel

• HISHIKAWA Yoshihiro

  Department of Research & Development, Ohkura Pharmaceutical Co., Ltd.

• KAKINO Yukari

  Department of Research & Development, Ohkura Pharmaceutical Co., Ltd.

• FURUKAWA Hidemitsu

  Department of Mechanical System Engineering, Soft & Wet Matter Engineering Laboratory (SWEL), Graduate School of Science and Engineering of Yamagata University

• TAHARA Kohei

  Department of Drug Delivery Technology and Science, Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University

• TAKEUCHI Hirofumi

  Department of Drug Delivery Technology and Science, Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University

Bibliographic Information

Other Title

• カンテンゲルおよびキサンタンガム–ローカストビーンガム混合ゲルの網目構造と薬物放出特性
• カンテンゲル オヨビ キサンタンガム-ローカストビーンガム コンゴウ ゲル ノ アミメ コウゾウ ト ヤクブツ ホウシュツ トクセイ

Abstract

Gel samples were prepared with agar and xanthan gum-locust bean gum and the rheological properties and network structures of the gels were measured. Gels including acetaminophen were also prepared and the dissolution of the acetaminophen from the gels was evaluated. When the concentration of the gels increased, the breaking stress increased in a concentration-dependent manner, while the distances between the crosslinking points of the gels became shorter. However, a relation between the breaking stress and the distance between the crosslinking points was not found by varying the kind of the gels. It is found that the difference of the gel structure decides the mesh size of the network. As a result of the dissolution characterization of acetaminophen from the gels the dissolution speed was found to be slower in xanthan gum-locust bean gum gel than in agar gel and this implies that it depends on the mesh size of the gels. This study shows that drug release is possibly controllable with the natural polymer gels by adjusting the mesh size of gels.

Journal

• KOBUNSHI RONBUNSHU

  KOBUNSHI RONBUNSHU 72 (2), 57-63, 2015

  The Society of Polymer Science, Japan

Keywords

• Natural Polymer Gel
• SMILS
• Gel Network Structure
• Drug Release

Details

• CRID: 1390282681502376576
• NII Article ID: 130004793181
• NII Book ID: AN00085011
• DOI: 10.1295/koron.2014-0036
• ISSN: 18815685
• ISSN: 03862186
• NDL BIB ID: 026183152
• Web Site: http://id.ndl.go.jp/bib/026183152
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026183152
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed