Serum level of galectin-3 in human bladder cancer

• Sakaki Manabu

  Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School

• Oka Natsuo

  Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School

• Nakanishi Ryoichi

  Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School

• Yamaguchi Kunihisa

  Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School

• Fukumori Tomoharu

  Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School

• Kanayama Hiro-omi

  Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School

抄録

We examine serum level of galectin-3 in patients with bladder cancer. We used serum samples of 67 patients with urological diseases and classified these patients into bladder cancer group (n=43) and control group (n=24). Galectin-3 concentration was measured by ELISA (Human Galectin-3 Assay Kit, IBL). And we selected the patient with high serum galectin-3 concentration (Urothelial Carcinoma, G3, pT3a pN0M0), we performed immunohistochemical staining with the VECTASTAIN ABC (Avidin Biotinylated enzyme Complex) system. Median value of serum galectin-3 concentration was 1068 pg/ml (range 551-2028) in the cancer group vs 584 pg/ml (range 259-1262) in controls. Serum galectin-3 concentration of the bladder cancer patients was statistically higher than that of controls (p<0.0005). There was no apparent correlation in serum galectin-3 concentration with the clinico-pathological features such as stage and grade. Higher expression of galectin-3 was observed in bladder cancer tissue than in normal bladder tissue. We suggest the measurement of serum galectin-3 is useful for diagnosis of bladder cancer. J. Med. Invest. 55: 127-132, February, 2008

収録刊行物

• The Journal of Medical Investigation

  The Journal of Medical Investigation 55 (1,2), 127-132, 2008

  国立大学法人　徳島大学医学部

キーワード

• galectin-3
• serum
• bladder cancer

詳細情報

• CRID: 1390001204242504576
• NII論文ID: 120006378411
• NII論文ID: 130004822572
• NII書誌ID: AA11166929
• DOI: 10.2152/jmi.55.127
• ISSN: 13496867
• ISSN: 13431420
• Web Site: https://repo.lib.tokushima-u.ac.jp/110849
• Web Site: http://www.jstage.jst.go.jp/article/jmi/55/1,2/55_1,2_127/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008264437
• 本文言語コード: en
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