Prognostic significance of HIF-2.ALPHA. expression on tumor infiltrating macrophages in patients with uterine cervical cancer undergoing radiotherapy

• Kawanaka Takashi

  Department of Radiology, The University of Tokushima Graduate School

• Kubo Akiko

  Department of Radiology, The University of Tokushima Graduate School

• Ikushima Hitoshi

  Department of Radiology, The University of Tokushima Graduate School

• Sano Toshiaki

  Department of Human Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School

• Takegawa Yoshihiro

  Department of Radiologic Technology, School of Health Sciences, The University of Tokushima

• Nishitani Hiromu

  Department of Radiology, The University of Tokushima Graduate School

抄録

Hypoxia-inducible factor (HIF)-2α, a basic helix-loop-helix (bHLH)-PAS protein, is the principal regulator of the hypoxic transcriptional response. An immunohistochemical study reported strong HIF-2α expression in the cytoplasm of tumor infiltrative macrophages (TIMs). Thus we assessed the expression of HIF-2α in human cervical cancer tissue before radiation therapy and its relationship to the clinical outcome. Seventy three patients with histologically proven primary advanced squamous cell carcinoma of the uterine cervix underwent radiotherapy in Tokushima University Hospital after biopsy specimens were taken. Among 73 specimens stained for HIF-2α, 53 (72.6%) exhibited HIF-2α immunoreactivity in the TIMs. In only 5 of 73 cases, HIF-2α immunoreactivity was observed in the nuclei of tumor cells. The HIF-2α positive cell count ratio in TIMs was associated with disease-free survival (DFS) with the worst DFS (p=0.024) being in cases in the group with a high positive cell count ratio. A high HIF-2α positive cell count ratio in TIMs increased the risk of local recurrence (p=0.0142). These findings might suggest that the ratio of the HIF-2α positive cell in TIMs may be a new predictive indicator for prognosis before radiation therapy for uterine cervical cancer. J. Med. Invest. 55: 78-86, February, 2008

収録刊行物

• The Journal of Medical Investigation

  The Journal of Medical Investigation 55 (1,2), 78-86, 2008

  国立大学法人　徳島大学医学部

キーワード

• hypoxia
• HIF-2 alpha
• macrophage
• uterine cervical cancer

詳細情報

• CRID: 1390001204242536832
• NII論文ID: 130004822587
• NII書誌ID: AA11166929
• DOI: 10.2152/jmi.55.78
• ISSN: 13496867
• ISSN: 13431420
• Web Site: http://www.jstage.jst.go.jp/article/jmi/55/1,2/55_1,2_78/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008264431
• 本文言語コード: en
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