E2F1-deficient NOD/SCID mice are an experimental model for dry mouth
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- Satoh Keitaro
- Department of Regulatory Physiology, Dokkyo Medical University School of Medicine Department of Physiology, Nihon University School of Dentistry at Matsudo
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- Narita Takanori
- Department of Physiology, Nihon University School of Dentistry at Matsudo
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- Matsui-Inohara Hikaru
- Department of Bacteriology, National Institute of Infectious Diseases
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- Ito Tatsuro
- Department of Bacteriology, National Institute of Infectious Diseases
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- Senpuku Hidenobu
- Department of Bacteriology, National Institute of Infectious Diseases
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- Sugiya Hiroshi
- Department of Physiology, Nihon University School of Dentistry at Matsudo
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Abstract
Saliva contains a wide variety of secretory proteins, including α-amylase, lysozyme, peroxidase, immunoglobulins, and mucins. Hyposecretion of saliva and consequent dry mouth will lead to severe dental caries, periodontal disease, and mucosal infections, resulting in degrade of quality of life. Polyposia development is one of sign usually seen in dry mouth patients. However, little is reported in dry mouth-model animal regarding the entire process of polyposia development. We investigated the behavior of polyposia in E2F1-deficient non-obese diabetic/severe combined immunodeficiency disease (NOD/SCID) mice, as a dry mouth-model. E2F1-deficient NOD/SCID mice secreted small amount of saliva under the stimulation with a cholinergic agonist, pilocarpine, compared with control mice. The frequency of water intake by E2F-1-deficient NOD/SCID mice was more than that by control mice. These results suggest that E2F-1-deficient NOD/SCID mice show a behavior similar to polyposia and are very useful experimental model of dry mouth patients. J. Med. Invest. 56 Suppl.: 260-261, December, 2009
Journal
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- The Journal of Medical Investigation
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The Journal of Medical Investigation 56 (Supplement), 260-261, 2009
The University of Tokushima Faculty of Medicine
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Details 詳細情報について
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- CRID
- 1390282679219574144
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- NII Article ID
- 130004822609
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- NII Book ID
- AA11166929
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- ISSN
- 13496867
- 13431420
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed