Characterization of neurokinin A-evoked salivary secretion in the perfused rat submandibular gland
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- Narita Takanori
- Department of Physiology, Nihon University School of Dentistry at Matsudo
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- Qi Bing
- Department of Physiology, Nihon University School of Dentistry at Matsudo
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- Fukano Mika
- Department of Physiology, Nihon University School of Dentistry at Matsudo
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- Matsuki-Fukushima Miwako
- Department of Physiology, Nihon University School of Dentistry at Matsudo
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- Murakami Masataka
- Department of Nano-Structure Physiology, National Institute for Physiological Sciences
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- Sugiya Hiroshi
- Department of Physiology, Nihon University School of Dentistry at Matsudo
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Abstract
Neurokinin A (NKA) evokes salivary secretion. Despite such reports, the direct effect of NKA on salivary secreteion in submandibular gland has not been clarified. Here we studied characterization of salivary fluid secretion induced by NKA in the perfused submandibular grand (SMG) of the rat. NKA (3-100 nM) stimulated salivary fluid secretion in a dose-dependent manner. The profile of secretion induced by NKA consisted of two phases, transient and sustained phases. When the gland was perfused with Lucifer yellow (LY)-containing perfusate buffer and stimulated by NKA, concentration of LY in saliva was increased. In the absence of Ca2+ in the perfusate, NKA induced only a transient salivary fluid and a transient LY secretion. When the gland was treated with BAPTA, NKA failed to induce both salivary fluid secretion and LY secretion. These results suggest that NKA induces salivary secretion via both transcellular and paracellular pathways, which depends on intracellular Ca2+ mobilization. J. Med. Invest. 56 Suppl.: 278-280, December, 2009
Journal
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- The Journal of Medical Investigation
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The Journal of Medical Investigation 56 (Supplement), 278-280, 2009
The University of Tokushima Faculty of Medicine
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Details 詳細情報について
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- CRID
- 1390001204243002368
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- NII Article ID
- 130004822616
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- NII Book ID
- AA11166929
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- ISSN
- 13496867
- 13431420
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed