Correlation of fibroblast growth factor 21 serum levels with metabolic parameters in Japanese subjects

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Author(s)

    • Jin Qing-Ri
    • Department of Life Systems, Institute of Technology and Science, the University of Tokushima
    • Bando Yukiko
    • Clinical Research Center for Diabetes, Tokushima University Hospital
    • Miyawaki Katsuyuki
    • Department of Life Systems, Institute of Technology and Science, the University of Tokushima
    • Shikama Yosuke
    • Clinical Research Center for Diabetes, Tokushima University Hospital
    • Kosugi Chisato
    • Clinical Research Center for Diabetes, Tokushima University Hospital
    • Aki Nanako
    • Clinical Research Center for Diabetes, Tokushima University Hospital|Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Funaki Makoto
    • Clinical Research Center for Diabetes, Tokushima University Hospital
    • Noji Sumihare
    • Diabetes Therapeutics and Research Center, the University of Tokushima

Abstract

Objects: Since serum level of fibroblast growth factor 21 (FGF21) has been implicated as a potential biomarker for the early detection of the metabolic syndrome and type 2 diabetes, we examined how FGF21 serum levels are correlated with metabolic parameters in Japanese subjects. Methods: FGF21 levels were analyzed by enzyme-linked immunosorbent assays. Spearman’s correlation and multiple stepwise regression analyses were used to examine the relationship between serum FGF21 and other factors. A Mann-Whitney <I>U</I> test was performed between the normal and high groups for triglycerides and systolic blood pressure (BP) respectively. Results: By univariate correlation analysis, serum FGF21 levels were significantly associated with triglyceride levels, systolic BP, diastolic BP, pulse pressure, body mass index (BMI), age, fasting plasma glucose (FPG) levels, and total cholesterol levels. Multiple regression analysis (adjusted for age, gender, and BMI) showed that serum FGF21 levels were independently and significantly associated with triglyceride levels and systolic BP. Serum FGF21 levels were significantly higher in subjects with high triglyceride levels and high systolic BP compared with those who had normal triglyceride levels and normal systolic BP respectively. Conclusions: This study found that FGF21 levels might be a biomarker for some metabolic disorders associated with metabolic syndrome. J. Med. Invest. 61: 28-34, February, 2014

Journal

  • The Journal of Medical Investigation

    The Journal of Medical Investigation 61(1.2), 28-34, 2014

    The University of Tokushima Faculty of Medicine

Codes

  • NII Article ID (NAID)
    130004822713
  • NII NACSIS-CAT ID (NCID)
    AA11166929
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1343-1420
  • Data Source
    IR  J-STAGE 
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