Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model

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Author(s)

    • Takechi Hirokazu
    • Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Minato Takuya
    • Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Furukita Yoshihito
    • Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Yamamoto Yota
    • Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Yuasa Yasuhiro
    • Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Yamai Hiromichi
    • Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Yoshida Takahiro
    • Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Seike Junichi
    • Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Tangoku Akira
    • Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Mawatari Kazuaki
    • Department of Preventive Environent and Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Harada Nagakatsu
    • Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Nakaya Yutaka
    • Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Asakura Megumi
    • Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Aihara Mutsumi
    • Department of Preventive Environent and Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Takizawa Hiromitsu
    • Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Goto Masakazu
    • Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Nishino Takeshi
    • Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School

Abstract

Supportive therapy during chemotherapy has become essential, but effective preventive therapies to gastrointestinal mucosal injury are few. We investigated the efficacy of glutamine in rat anticancer drug-induced enteritis model. In this study, we used twenty male SD rats. They were divided into control, 5-fluorouracil (5-FU) (orally administered at 20 mg/kg day), 5-FU+glutamine (1000 mg/kg/day) and 5-FU+glutamine+fiber and oligosaccharide (GFO<SUP>®</SUP>) (1000 mg/kg/day) groups. All groups were sacrificed on day 6 and upper jejunums were excised. The jejunal villous height was measured in specimens. IgA level in jejunal washing solution, and serum diamine oxidase activity were also measured. The jejunal villous height was recognized as shorter in the specimen from 5-FU treated rats compared with 5-FU+glutamine treated rats (p<0.001). Serum diamine oxidase activity in 5-FU+glutamine group were significantly superior to that in 5-FU group (p=0.028). IgA level in jejunal washing solution tended to be higher in 5-FU+glutamine group than that in 5-FU group (p=0.076). On the other hand, serum diamine oxidase activity and IgA level in jejunal washing solution showed no significant difference between 5-FU+GFO and 5-FU treatment group. Our results suggest that glutamine showed protective effects on mucosal injury of small intestine in rat anticancer drug-induced enteritis model. J. Med. Invest. 61: 59-64, February, 2014

Journal

  • The Journal of Medical Investigation

    The Journal of Medical Investigation 61(1.2), 59-64, 2014

    The University of Tokushima Faculty of Medicine

Codes

  • NII Article ID (NAID)
    130004822718
  • NII NACSIS-CAT ID (NCID)
    AA11166929
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1343-1420
  • Data Source
    IR  J-STAGE 
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