Treatment with buckwheat bran extract prevents the elevation of serum triglyceride levels and fatty liver in KK-Ay mice.

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  • Hosaka Toshio
    Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School Third Department of Internal Medicine, Kyorin University School of Medicine
  • Sasaga Sayaka
    Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
  • Yamasaka Yukiko
    Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
  • Nii Yoshitaka
    Food Technology Division, Tokushima Prefectural Industrial Technology Center
  • Edazawa Kazuhiro
    TANI FOOD Corporation, Ltd.
  • Tsutsumi Rie
    Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
  • Shuto Emi
    Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
  • Okahisa Naoki
    Food Technology Division, Tokushima Prefectural Industrial Technology Center
  • Iwata Shinya
    Food Technology Division, Tokushima Prefectural Industrial Technology Center
  • Tomotake Hiroyuki
    Iida Women's Junior College
  • Sakai Tohru
    Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School

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  • Treatment with buckwheat bran extract prevents the elevation of serum triglyceride levels and fatty liver in KK-A<sup>y </sup>mice.

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Buckwheat powder or protein has been shown to decrease the total serum cholesterol level in non-diabetic mice or rats. However, the lipid-lowering effect of buckwheat bran extract (BBE) in diabetic mice has not been fully elucidated. KK-Ay mice that received six-week treatment with BBE showed decreased body weight and liver weight compared to those of control (vehicle) mice. However, there was no significant difference in food intake. BBE treatments prevented liver triglyceride accumulation and decreased the serum level of triglycerides. In addition, mRNA expression levels lipogenic enzyme genes, fatty acid synthase, acetyl-coenzyme a oxidase and stearyl-coenzyme a desaturase 1, but not those of β-oxidized enzyme genes, were decreased in BBE-treated mice. Level of transcription factors ChREBP and SREBP1c, transcripts of lipogenic genes, were also decreased in BBE-treated mice. These results suggest that chronic treatment with BBE derivatives could have beneficial effects on hypertriglycemia in patients with type 2 diabetes mellitus. J. Med. Invest. 61: 345-352, August, 2014

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