切断指再接着術後の動脈攣縮に対するLipo PGE₁局所持続動脈内注入法

• 長谷川 健二郎

  川崎医科大学整形外科

• 仁井谷 学

  川崎医科大学整形外科

• 清水 雅恵

  川崎医科大学整形外科

• 中條 武秀

  川崎医科大学整形外科

• 三河 義弘

  川崎医科大学整形外科

書誌事項

タイトル別名

• Local Continuous Intra-Arterial Infusion of Lipo PGE₁ for Arterial Spasm after Replantation of an Amputated Finger

抄録

A 50-year-old female experienced complete amputation of the left thumb, index finger and middle finger (zone 3) and a 35 year-old male had complete amputation of the right ring finger (zone 4). In both cases, strong spasms occurred from two days after replantation. The skin temperature fell to below 31°C, and SpO₂was around 80%. Therefore, local continuous intra-arterial infusion of Lipo PGE₁ was conducted. Lipo PGE₁ 10μg and heparin 6000 units were dissolved in physiological saline and totaled 48 ml. A 22G catheter was placed into the radial artery, and a syringe pump was used to infuse the solution continuously at a rate of 4-6 mg/h. Immediately after infusion was started, SpO₂ improved to over 96% and skin temperature also improved gradually. The catheter was removed after 14 days of infusion, and the replanted fingers survived. Lipo PGE₁ is effective in resolving arterial spasm at initial doses of 0.25-0.38 ng/kg/min and a maintenance dose of 0.13 ng/kg/min.

収録刊行物

• 中国・四国整形外科学会雑誌

  中国・四国整形外科学会雑誌 17 (1), 43-49, 2005

  中国・四国整形外科学会

キーワード

• 再接着術
• リポプロスタグランジンE1
• 薬物送達システム製剤
• 攣縮

詳細情報

• CRID: 1390282679326334336
• NII論文ID: 130004839042
• DOI: 10.11360/jcsoa.17.43
• ISSN: 13475606
• ISSN: 09152695
• Web Site: https://search.jamas.or.jp/link/ui/2005223350
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可