A role of Cystatin SN for sensitization and onset of seasonal allergic rhinitis by Japanese cedar pollen

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  • Imoto Yoshimasa
    Department of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
  • Tokunaga Takahiro
    Department of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
  • Fujieda Shigeharu
    Department of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui

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  • スギ花粉症の感作・発症とCystatin SN の役割

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Abstract

The mechanisms of allergic rhinitis from sensitization to onset had not been well revealed. We had performed gene expression analysis of nasal epithelial cells by using microarray toward patients with seasonal allergic rhinitis by Japanese cedar pollen (SAR-JCP) and healthy, non-atopic subjects (control subjects). We found that Cystatin SN was up-regulated in SAR-JCP than control subjects. We also invited subjects who possess specific IgE against JCP in serum but had not experienced any SAR-JCP related symptoms “Sensitized subjects” and analyzed Cystatin SN expression. Because some showed higher expression pattern of Cystatin SN among sensitized subjects, it was suspected that Cystatin SN was one of the candidate genes that related the onset from sensitization phase. Cystatin SN belongs to Cystatin family and acts as protease inhibitor. Cystatins have anti-protease activity against not only exogenous protease such as pollen, bacteria, and fungi, but also endogenous protease such as cathepsin, which contribute to inflammation, tissue repair, and cell proliferation. This review summarize the functions of Cystatin SN in nasal epithelial cells and developing allergic rhinitis.

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