Serial changes in values of cerebral regional saturation of oxygen (rSO<SUB>2</SUB>) during resuscitation in patients with out-of-hospital cardiac arrest

• Nakahori Yasutaka

  Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine Department of Emergency Medicine, Osaka General Medical Center

• Hirose Tomoya

  Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine

• Shiozaki Tadahiko

  Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine

• Ogawa Yoshihito

  Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine

• Ohnishi Mitsuo

  Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine

• Fujimi Satoshi

  Department of Emergency Medicine, Osaka General Medical Center

• Shimazu Takeshi

  Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine

Bibliographic Information

Other Title

• 病院外心肺停止患者に対する蘇生処置中の脳内酸素飽和度（rSO<SUB>2</SUB>）の継時的変化
• Serial changes in values of cerebral regional saturation of oxygen (rSO2) during resuscitation in patients with out-of-hospital cardiac arrest

Abstract

Background: Regional saturation of oxygen (rSO₂), also known as “tissue oxygen saturation” or “local mixed blood oxygen saturation”, indicates the overall oxygen saturation including the arteries, veins and capillaries. The change in the balance of oxygen supply and demand can be determined by measuring this value. Although protection of the patient’s brain is emphasized in cardiopulmonary arrest, no studies have investigated tissue oxygenation of the brain during resuscitation.<BR>Objective: To clarify serial changes in cerebral rSO₂ during resuscitation of patients with out-of-hospital cardiac arrest.<BR>Methods: We retrospectively analyzed date from patients with out-of-hospital cardiac arrest in whom cerebral rSO₂ were measured serially between March 2008 and March 2010. Patients were divided into the ROSC (return of spontaneous circulation) (+) group, ROSC (-) group, and PCPS (percutaneous cardiopulmonary support) group. Normal range of rSO₂ was determined from 15 healthy patients to be 71.2±3.9%.<BR>Results: The ROSC (-) group consisted of 25patients (mean age, 71.0±15.9 [mean±SD] years), the ROSC (+) group 13 patients (72.1±9.6 years), and the PCPS group 5 patients (54.4±15.8 years). Chest compression only could not increase cerebral rSO₂, but rSO₂ markedly increased with ROSC. Mean rSO2 at ROSC was 43.2±14.1%, and it increased significantly after 10 minutes (55.7±12.3%; p<0.05) and 15 minutes (59.7±8.5%; p<0.01). In the PCPS group, rSO₂ values were 63.0±8.8% after 5 minutes, 66.2±5.7% after 10 minutes, and 68.1±4.6% after 15 minutes, significant increases compared with 48.4±8.9% at the time of PCPS application (all, p<0.0001).<BR>Conclusions: Chest compression only could not increase cerebral rSO₂, but it increased gradually with ROSC. Cerebral rSO₂ increased promptly with application of PCPS.

Journal

• Nihon Kyukyu Igakukai Zasshi

  Nihon Kyukyu Igakukai Zasshi 24 (9), 774-780, 2013

  Japanese Association for Acute Medicine

Keywords

• return of spontaneous circulation (ROSC)
• cardiopulmonary arrest on arrival (CPAOA)
• percutaneous cardiopulmonary support (PCPS)

Details

• CRID: 1390001204369229056
• NII Article ID: 130004840972
• DOI: 10.3893/jjaam.24.774
• ISSN: 18833772
• ISSN: 0915924X
• Web Site: https://search.jamas.or.jp/link/ui/2014055820
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed