Seasonal Variation in Serum Lipid Levels in Japanese Workers

DOI PubMed 7 Citations 22 References
  • Kamezaki Fumihiko
    Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health. Nuclear Science Research Institute, Tokai Research and Development Center, Japan Atomic Energy Agency.
  • Sonoda Shinjo
    Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health.
  • Tomotsune Yusuke
    Nuclear Science Research Institute, Tokai Research and Development Center, Japan Atomic Energy Agency.
  • Yunaka Hiromi
    Nuclear Science Research Institute, Tokai Research and Development Center, Japan Atomic Energy Agency.
  • Otsuji Yutaka
    Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health.

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Abstract

Aim: Seasonal variation in serum lipid levels in the Japanese population remains unclear. The aim of this study was to determine whether a variation in lipid levels exists in Japanese workers.<BR>Methods: We investigated 1,331 employees in our institution (1,192 men, 44±10 years; 139 women, 38±11 years) who underwent health checkups in both June (summer) and December (winter), 2008.<BR>Results: Serum levels of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, and triglyceride were significantly higher in winter than in summer (129.1±31.2 mg/dL versus 125.2±30.2 mg/dL, p<0.0001; 65.9±16.8 mg/dL versus 63.5±16.1 mg/dL, p<0.0001; 110.4±67.5 mg/dL versus 107.5±70.4 mg/dL, p<0.05; respectively), although the ratio of LDL to HDL cholesterol was comparable (2.11±0.81 in summer versus 2.12±0.81 in winter). The frequency of study subjects diagnosed with hypercholesterolemia, defined as LDL cholesterol ≥140 mg/dL, was significantly higher in winter than in summer (34.5 % versus 30.9 %, p<0.0001).<BR>Conclusion: In Japanese workers, we demonstrated that there is a seasonal variation in serum lipid levels and the prevalence of hypercholesterolemia. This result indicates that we have to give careful consideration to the season of blood sampling in the clinical diagnosis of and management decisions for hypercholesterolemia.

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