Fasting Serum Apolipoprotein B-48 Can be a Marker of Postprandial Hyperlipidemia

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Author(s)

    • Masuda Daisaku
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
    • Yuasa-Kawase Miyako
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
    • Ohama Tohru
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.|Health Care Center, Osaka University.
    • Nakagawa-Toyama Yumiko
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.|Health Care Center, Osaka University.
    • Nishida Makoto
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.|Health Care Center, Osaka University.
    • Ishigami Masato
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.|Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine.
    • Masuda Yoshiro
    • Clinical Research Department, Pharmaceutical Division, Japan Tobacco Inc.
    • Matsuyama Akifumi
    • Department of Somatic Stem Cell Therapy, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation.
    • Komuro Issei
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
    • Yamashita Shizuya
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
    • Yamashita Taiji
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
    • Kawase Ryota
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
    • Nakaoka Hajime
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
    • Inagaki Miwako
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
    • Nakatani Kazuhiro
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.

Abstract

Aim: Postprandial hyperlipidemia (PH) is thought to be caused by the impaired postprandial metabolism of triglycerides (TG)-rich lipoproteins in both endogenous and exogenous pathways; however, there is no consensus. It is difficult to estimate the presence of PH without performing a time-consuming oral fat loading (OFL) test, so postprandial lipoprotein metabolism was analyzed by measuring the postprandial levels of apolipoprotein (apo) B-48 and apo B-100, and the correlation between postprandial TG increase and fasting apoB-48 levels was assessed to establish a good marker of PH without performing an OFL test.<BR>Methods: Ten male normolipidemic subjects were loaded with a high-fat (HF, 1045 kcal) or standard (ST, 566 kcal) meal, and the lipids, apolipoproteins and lipoprotein profiles were analyzed after each meal.<BR>Results: TG, apo B-48, remnant-like particles (RLP)-cholesterol and RLP-TG levels were increased and their levels were significantly higher after intake of the HF meal than the ST meal; however, there was no postprandial increase in apo B-100 and LDL-C levels. Postprandial increases in TG levels of CM, VLDL, LDL and HDL were significantly higher after intake of the HF meal than the ST meal. Fasting apo B-48 levels were strongly correlated with the incremental area under the curve of TG after intake of the HF meal, but not the ST meal.<BR>Conclusion: Postprandial TG increase was mainly due to increased CM and CM-R, but not VLDL. Measurement of fasting serum apo B-48 may be a simple and useful method for assessment of the existence of PH.

Journal

  • Journal of Atherosclerosis and Thrombosis

    Journal of Atherosclerosis and Thrombosis 18(12), 1062-1070, 2011

    Japan Atherosclerosis Society

Codes

  • NII Article ID (NAID)
    130004845356
  • Text Lang
    ENG
  • ISSN
    1340-3478
  • Data Source
    J-STAGE 
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