Ezetimibe Monotherapy Ameliorates Vascular Function in Patients with Hypercholesterolemia Through Decreasing Oxidative Stress

DOI 6 Citations 29 References
  • Kurobe Hirotsugu
    Department of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School.
  • Aihara Ken-ichi
    Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School.
  • Higashida Mayuko
    Department of Nutrition & Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School.
  • Hirata Yoichiro
    Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School.
  • Nishiya Masako
    Division of Nursing, Tokushima University Hospital.
  • Matsuoka Yuki
    Department of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School.
  • Kanbara Tamotsu
    Department of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School.
  • Nakayama Taisuke
    Department of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School.
  • Kinoshita Hajime
    Department of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School.
  • Sugano Mikio
    Department of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School.
  • Fujimoto Eiki
    Department of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School.
  • Kurobe Ayako
    Division of Nursing, Tokushima University Hospital.
  • Sugasawa Noriko
    Department of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School.
  • Kitaichi Takashi
    Department of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School.
  • Akaike Masashi
    Department of Medical Education, Institute of Health Biosciences, The University of Tokushima Graduate School.
  • Sata Masataka
    Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School.
  • Matsumoto Toshio
    Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School.
  • Kitagawa Tetsuya
    Department of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School.

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Abstract

Aim: Ezetimibe, an inhibitor of cholesterol intestinal absorption, is a lipid lowering agent. However, anti-atherogenic effects of ezetimibe have not been fully elucidated. Therefore, the objective in this study was to clarify the vascular protective effects of ezetimibe in patients with hypercholesterolemia.<BR>Methods: Ezetimibe was administered to 20 patients with hypercholesterolemia (group E), and 20 age- and sex-matched patients with hypercholesterolemia were followed as controls (group C). Difference in metabolic profiles and cardiovascular surrogate markers before ezetimibe treatment and after 12 weeks of ezetimibe treatment were statistically evaluated.<BR>Results: Ezetimibe treatment significantly reduced serum levels of low-density lipoprotein cholesterol (LDL-C) and malondialdehyde-modified low-density lipoprotein (MDA-LDL). In addition, the values of body mass index, body weight, waist circumference, plasma HbA1c and urinary albumin were significantly decreased in group E compared to those in group C. On the other hand, high-density lipoprotein cholesterol (HDL-C) and adiponectin levels were significantly increased in group E compared to those in group C. The values of brachial-ankle pulse wave velocity (ba-PWV), mean arterial blood pressure (m-ABP), and % of flow-mediated dilation (FMD) were significantly improved in group E. Furthermore, ultrasonic studies demonstrated amelioration of the vascular stiffness of common carotid arteries in group E but not in group C. These vascular protective effects of ezetimibe were statistically correlated with the decreased values of MDA-LDL and MDA-LDL-to-LDL-C ratio but not with those of LDL-C.<BR>Conclusion: Ezetimibe has a lipid lowering-independent vascular protective effect in patients with hypercholesterolemia through decreasing oxidative stress.

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